CClinicalTrials.gg
Not yet recruitingNCT07574801Updated May 8, 2026

Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers

An interventional study of root canal treatment and root canal treatment in Root Canal Treatment and Irreversible Acute Pulpitis, sponsored by Cairo University. Not yet recruiting. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-05-08.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers

02

Conditions studied

  • Root Canal Treatment
  • Irreversible Acute Pulpitis

Browse trials for

Keywords

  • postoperative pain
  • bioceramic sealer
  • extrusion
  • root canal treatment
03

In context

Pain, Postoperative

5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.

This study's planned enrollment of 30 is below the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.

Browse Pain, Postoperative studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Molar teeth requiring root canal treatment
  2. Diagnosed with symptomatic irreversible pulpitis,
  3. Patients able to understand and use the VAS scale

Exclusion criteria

Exclusion Criteria:

  1. Patients with systemic diseases affecting pain perception
  2. Use of analgesics within 12 hours before treatment
  3. Previously treated teeth
  4. Teeth with periapical abscess or swelling
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    nanosealer flo

    bioceramic sealer

    Procedure: root canal treatment

  • Active comparator
    ceraseal

    bioceramic sealer

    Procedure: root canal treatment

Interventions

  • Procedureroot canal treatment

    nanosealer flo bioceramic root canal sealer

  • Procedureroot canal treatment

    cerseral bioceramic root canal sealer

06

What researchers measure

Primary outcomes

  1. postoperative pain

    postoperative pain will be measured using a visual analogue scale ( after being introduced and discussed with the patient) at 2 time points, pain will be categorized as no pain, moderate and severe.

    Time frame: 24 and 48 hours

Secondary outcomes

  1. sealer extrusion

    sealer extrusion will be measured radiographically using standardized digital periapical posttreatment radiographs via a blinded examiner and recorded as binary outcome: present/ absent.

    Time frame: immediate postoperatively

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07574801
Lead sponsor
Cairo University
Responsible party
sara Gamal Ahmed (clinical ass. professor, principal investigator, endodontic department, Cairo University) — Principal investigator
First posted
May 8, 2026
Start date
May 1, 2026 (estimated)
Primary completion
Sep 1, 2026 (estimated)
Completion
Sep 8, 2026 (estimated)
Last update
May 8, 2026

Study contacts

Sara Gamal Elgamal
Contact
sara.elgamal@dentistry.cu.edu.eg
00201094557105
Heba ibrahim Mohammady
Contact
heba.mohamdy@dentistry.cu.edu.eg

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion