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CompletedNCT07574372Updated May 7, 2026

Effect of ERAS and Upper Limb Exercise on LoS After Modified Radical Mastectomy

An interventional study of Enhanced Recovery After Surgery and Upper Limb Exercise in Modified Radical Mastectomy, sponsored by Prof. R. D. Kandou General Hospital. Completed at 1 site in Indonesia. Open to female participants aged 30 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-05-07.

Sponsored by Prof. R. D. Kandou General Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 6 months after the study started (first participant enrolled Oct 2024, registered Apr 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
24
Allocation
Randomized
Ages
30 Years to 65 Years
Sex
Female
01

Study summary

The goal of this clinical trial is to learn if Enhanced Recovery After Surgery (ERAS) protocol and upper limb exercise shorten the length of stay (LoS) in adults after modified radical mastectomy (MRM) surgery. The main questions it aims to answer are:

  • Do ERAS protocol and upper limb exercise shorten the LoS after modified radical mastectomy (MRM)? Researchers will compare the ERAS protocol and upper limb exercise intervention to standard care to determine whether these interventions reduce LoS.

Four weeks before surgery, participants in intervention group will do:

  • Aerobic exercise by walking for 30 minutes at moderate intensity (Borg scale 12-14) with frequency twice a week and by cycling for 30 minutes at moderate intensity (40-60% HRR / 64-76% HRmax/RPE 12-14) with frequency three times a week.
  • Strengthening exercise of lower limbs three times a week, intensity 60-80% 1RM, 3 set, 10 repetition, rest 60 seconds between sets by machine pulley.
  • Strengthening exercise of upper limbs at intensity 60-80% 1RM, frequency three times a week, 10 repetition, rest 60 seconds by bench press and cable front raise.
  • Stretching exercise of upper limbs and range of motion exercise frequency three times a week, hold 10 seconds, by static stretching.

After surgery, both groups will do:

  • Mobilization, ambulation, and shoulder range of motion exercise in first 24 hours after surgery.
02

Conditions studied

  • Modified Radical Mastectomy

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Keywords

  • Enhanced Recovery After Surgery
  • Prehabilitation
  • Exercises
03

In context

Motor Activity

9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.

This study's enrollment of 24 is below the median of 60 across 8,388 interventional studies indexed under Motor Activity.

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Lead sponsor

Prof. R. D. Kandou General Hospital is the lead sponsor of 3 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 65 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Women aged 30-65 years
  2. Diagnosed with breast cancer by histopathological examination and will undergo the first MRM surgery
  3. Planned to undergo chemotherapy
  4. Hemodynamically stable (assessed by vital signs)
  5. (MMSE) score > 25
  6. Comorbid diseases are controlled
  7. Corrected nutritional status
  8. No balance or coordination disorders
  9. Normal or corrected vision function
  10. Normal hearing function as tested by whisper test
  11. Willing and agree to participate in the study until completion and sign

Exclusion criteria

Exclusion Criteria:

  1. Presence of distant
  2. Presence of lymphedema
  3. Limited joint range of motion
  4. Other cardiovascular conditions that contraindicate physical exercise according to the American College of Sports Medicine (ACSM) guidelines
Terms in these criteria, in plain language(4)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Adjuvant and neoadjuvant

Neoadjuvant treatment is given before the main treatment (usually surgery), often to shrink a tumour. Adjuvant treatment is given after it, to lower the chance of the cancer coming back.

MMSE and MoCA

Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Metastases

Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
24 participants (actual)

Study arms

  • Experimental
    ERAS protocol and upper limb exercises

    ERAS protocol and upper limb exercises

    Behavioral: Enhanced Recovery After Surgery · Behavioral: Upper Limb Exercise

  • No intervention
    Standard Care

    Standard Care

Interventions

  • BehavioralEnhanced Recovery After Surgery

    Four weeks before surgery, participants in intervention group will do: * Aerobic exercise by walking for 30 minutes at moderate intensity (Borg scale 12-14) with frequency twice a week and by cycling for 30 minutes at moderate intensity (40-60% HRR / 64-76% HRmax/RPE 12-14) with frequency three times a week. * Strengthening exercise of lower limbs three times a week, intensity 60-80% 1RM, 3 set, 10 repetition, rest 60 seconds between sets by machine pulley.

  • BehavioralUpper Limb Exercise

    Four weeks before surgery, participants in intervention group will do: * Strengthening exercise of upper limbs at intensity 60-80% 1RM, frequency three times a week, 10 repetition, rest 60 seconds by bench press and cable front raise. * Stretching exercise of upper limbs and range of motion exercise frequency three times a week, hold 10 seconds, by static stretching.

06

What researchers measure

Primary outcomes

  1. Length of Stay

    Length of stay after Modified Radical Mastectomy

    Time frame: From the date of surgery until hospital discharge, assessed up to 10 days

07

Study locations

1 site
  • Prof. Dr. R. D. Kandou General Hospital
    Manado, North Sulawesi, Indonesia
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 7, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07574372
Lead sponsor
Prof. R. D. Kandou General Hospital
Responsible party
Sponsor
First posted
May 7, 2026
Start date
Oct 1, 2024
Primary completion
Mar 31, 2025
Completion
Mar 31, 2025
Last update
May 7, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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