An interventional study of Intralesional exosomes and Intralesional Saline in Atrophic Scar, sponsored by Zagazig University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-06.
Sponsored by Zagazig University · Not applicable, Interventional, and Treatment
Lay Summary (Simple Explanation)
Atrophic scars are depressed scars that form when the skin does not heal properly, commonly seen after acne or injuries. These scars can affect appearance and confidence, and current treatments may not always give satisfactory results.
This study aims to evaluate a new treatment using exosomes, which are tiny particles naturally released by cells that help in skin repair and regeneration. Researchers will compare the effect of injecting exosomes directly into scars versus injecting a simple saltwater solution (saline), which serves as a control.
Participants will be randomly assigned to receive either exosome injections or saline injections. Neither the patient nor the evaluator may know which treatment is given, to ensure fair comparison.
The goal is to determine whether exosomes can safely and effectively improve the appearance and texture of atrophic scars.
Zagazig University is the lead sponsor of 447 studies on the registry; 75 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Age >18 years
Exclusion Criteria:
Other: Intralesional exosomes
Other: Intralesional Saline
exosomes are injected within the substance of the scar.
all patients will receive both, exosomes and saline, each injected into one scar.
modified Manchester Scar Scale
Scar appearance was assessed using the Modified Manchester Scar Scale. The Modified Manchester Scar Scale ranges from 4 to 24, with lower scores indicating better scar appearance and higher scores indicating worse scar appearance
Time frame: 3 months after 4 biweekly sessions
Scar thickness measurement in millimetres by Ultrasound examination
Scar characteristics, including scar thickness and echogenicity, will be assessed using high-frequency ultrasound examination. Scar thickness will be measured in millimeters, and changes from baseline to follow-up will be summarized. Higher scar thickness values indicate greater scar tissue thickness
Time frame: 3 months after 4 biweekly sessions
Plan to share: No
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Zagazig University