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CompletedNCT07560332Updated May 1, 2026

Oral Propranolol Versus Fractional Carbon Dioxide CO2 Laser Assisted Delivery of Topical Timolol for Treatment of Infantile Hemangioma

An interventional study of Propranolol 1 and Fractional CO2 laser with topical timolol in Infantile Hemangioma (IH), sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 1 Month to 12 Years. Per ClinicalTrials.gov, last updated 2026-05-01.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 3 months after the study started (first participant enrolled Jan 2025, registered Apr 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
1 Month to 12 Years
Sex
All
01

Study summary

To assess and compare the efficacy of systemic beta-blocker therapy with the efficacy and safety of fractional carbon dioxide laser-assisted delivery of a topical beta-blocker solution in the treatment of infantile hemangioma.

02

Conditions studied

  • Infantile Hemangioma (IH)

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Keywords

  • propranolol
  • timolol
  • carbon dioxide laser
  • infantile hemangioma
03

In context

Hemangioma, Capillary

83 studies on the registry are indexed under Hemangioma, Capillary; 8 are open to participants now.

This study's enrollment of 30 is close to the median of 33 across 56 interventional studies indexed under Hemangioma, Capillary.

Browse Hemangioma, Capillary studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
1 Month to 12 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

, aged 1 month to 12 years

- presenting with superficial, deep, mixed, or proliferating IH.

Exclusion criteria

Exclusion Criteria:

  • other cutaneous or systemic infections
  • chronic systemic diseases
  • known allergy to topical timolol maleate
  • contraindications to laser or beta-blocker therapy
  • IH involving mucosal or perimucosal sites
  • and a history of adverse reactions to laser therapy or keloid tendency.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
30 participants (actual)

Study arms

  • Active comparator
    Propranolol

    oral propranolol group for treatment of infantile hemangioma

    Drug: Propranolol 1

  • Experimental
    Topical timolol with fractional CO2 laser treatment of infantile hemangioma

    weekly session of fractional CO2 laser with topical timolol application

    Device: Fractional CO2 laser with topical timolol

Interventions

  • DrugPropranolol 1

    oral propranolol is given daily in a dose of 1 to 2 mgékg daily for 3 months

  • DeviceFractional CO2 laser with topical timolol

    Weekly sessions were performed followed by application of timolol daily

06

What researchers measure

Primary outcomes

  1. Improvement of global assessment score of infantile hemangioma

    Time frame: 3 months

07

Study locations

1 site
  • Cairo University
    Cairo, 11562, Egypt
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 1, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07560332
Lead sponsor
Cairo University
Responsible party
Amira Elbendary (Lecturer, Dermatology Department, Cairo University) — Principal investigator
First posted
May 1, 2026
Start date
Jan 1, 2025
Primary completion
Jan 1, 2026
Completion
Jan 1, 2026
Last update
May 1, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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