ClinicalTrials.gg
Not yet recruitingNCT07555821Updated Apr 29, 2026

Improving Postoperative Analgesia After Functional Endoscopic Surgery

A Phase 2/3 interventional study of Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine in Pain Management After Functional Endoscopic Sinuscopy, sponsored by South Egypt Cancer Institute. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-04-29.

Sponsored by South Egypt Cancer Institute · Phase 2/3, Interventional, and Supportive care

Phase
Phase 2/3
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 299 studies in Pain with a site in Egypt — 64 open to participants now, 79 under way, 5 of them phase 3. Pain · Egypt.

Planned enrollment
278th of 285
20 · median 62
Started
2026
with 25 others
Phase 2/3
12 of 299
2 open now
Primary completion
2026-10
later than 59 of 78 live
Registered
278th of 299
by date

Among the 299 studies in Pain with a site in Egypt, this one is the 278th largest by planned enrollment of the 285 interventional ones that give a count, is one of 26 that started in 2026, is one of 12 in phase 2/3, reaches primary completion later than 59 of the 78 other live ones, and was the 278th registered.

Pain

10,054 studies on the registry are indexed under Pain; 1,649 are open to participants now.

Browse Pain studies →

Open to participants now

64 of the 299 studies in Pain with a site in Egypt are open now. Recruiting first, the newest first:

59 more — sign in →

All 64 open studies →

A study can be open while its sites in Egypt have not opened yet or have stopped. Only those recruiting at a site in Egypt →

Who these studies take

Of the 929 Pain studies recruiting now, 384 (41%) set no upper age limit and 434 (47%) stop at 75 or younger; 146 take children under 18; 222 take healthy volunteers.

This study: 18 Years to 60 Years · all sexes · no healthy volunteers.

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02

Study summary

Improving postoperative analgesia after functional endoscopic surgery: Sphenopalatine ganglion block versus soaked nasal packing using bupivacaine and dexmedetomidine

03

Conditions studied

  • Pain Management After Functional Endoscopic Sinuscopy

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04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Age 18 - 60 years
  2. I -II
  3. Patients scheduled for elective FESS

Exclusion criteria

Exclusion Criteria:

  1. Allergy to drugs used
  2. Coagulopathy or anticoagulant therapy
  3. Severe cardiovascular, renal and hepatic disease
  4. Chronic opioid use Pregnancy
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

ASA physical status

The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.

05

Study design

Phase
Phase 2 / Phase 3
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Factorial assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    group a

    Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

    Drug: Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

  • Experimental
    druop b

    Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

    Drug: Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

Interventions

  • DrugSphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

    Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

06

What researchers measure

Primary outcomes

  1. effectiveness of SPGB with bupivacaine and dexmedetomidine for postoperative analgesia

    Numeric rating scale for pain will be assessed and recorded within the first 24 hours where 1 means the worst pain and 10 means no pain. Total rescue analgesia in 24 H when Numeric rating scale ≥ 4 was recorded and the first time when it was given will be recorded.

    Time frame: 6 months

07

Study locations

1 site
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Apr 2026; primary completion for Oct 2026, 6 months later.

Of 35 non-industry phase 2/3 interventional studies under Pain, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 13 and three quarters within 51. This study's planned 6 months is below that.

Counting every sponsor, half of 41 studies reached it within 20 months; a quarter within 13 and three quarters within 30.

How these figures are worked out, and which studies are left out of them.

Registered
Apr 14, 2026
First posted
Apr 29, 2026
StartEst.
Apr 15, 2026
Primary completionEst.
Oct 30, 2026
CompletionEst.
Oct 30, 2026
Last update
Apr 29, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07555821
Lead sponsor
South Egypt Cancer Institute
Responsible party
Ahmed Kamal Sayed (anesthesia consultant, Assiut University) — Principal investigator
First posted
Apr 29, 2026
Start date
Apr 15, 2026 (estimated)
Primary completion
Oct 30, 2026 (estimated)
Completion
Oct 30, 2026 (estimated)
Last update
Apr 29, 2026

Study contacts

Sara Mansour Mansour
Contact
saram@aun.edu.eg
1061092528 ext. 0020
Ahmed Kamal Attia
Contact
ahmedkamal86anathesia@gmail.com
1010677881 ext. 0020

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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