CompletedNCT07550829Updated Apr 24, 2026

Effects of CE on the Risk of Arteriosclerosis in SED Postmenopausal Women

An interventional study of AE group and RE group in Sedentary, sponsored by Beijing Sport University. Completed at 1 site in China. Open to female participants aged 45 Years to 69 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-24.

Sponsored by Beijing Sport University · Not applicable, Interventional, and Prevention

From the registry’s dates

Registered 1 year 2 months after the study started (first participant enrolled Feb 2025, registered Apr 2026).

Phase: Not applicable
Study type: Interventional
Enrollment: 113
Allocation: Randomized
Ages: 45 Years to 69 Years
Sex: Female

Study summary

This study investigated the effects of three exercise modalities: aerobic exercise, resistance exercise, and combined exercise on the risk of arteriosclerosis in sedentary postmenopausal women.

Read the detailed description

This study aims to compare the effects of different kinds of exercise on the risk of arteriosclerosis in sedentary postmenopausal women. Participants were recruited and randomly assigned to aerobic exercise, resistance exercise, combined exercise or control group. The intervention lasted for 12 weeks. Endothelial function indicators, chronic inflammation indicators, arteriosclerosis related indicators, blood pressure indicators were assessed before and after the intervention.

Conditions studied

Sedentary

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Keywords

Combined exercise
Arteriosclerosis
Sedentary
Postmenopausal women

In context

Sedentary Behavior

1,273 studies on the registry are indexed under Sedentary Behavior; 300 are open to participants now.

This study's enrollment of 113 is above the median of 60 across 1,076 interventional studies indexed under Sedentary Behavior.

Browse Sedentary Behavior studies →

Lead sponsor

Beijing Sport University is the lead sponsor of 54 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 45 Years to 69 Years
Sexes eligible: Female
Accepts healthy volunteers: Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Participants have been for more than 12 months and have not received any exogenous estrogen supplementation after menopause.
Participants were screened using the International Physical Activity Questionnaire-Short Form (IPAQ-S), with a physical activity level classified as "low." They must not have engaged in moderate-intensity physical activity for at least 3 days per week, with a duration of no less than 30 minutes per day, for over 3 consecutive months.
Participants were screened using the Physical Activity Readiness Questionnaire+ (PAR-Q+) and be deemed safe to undergo further intervention.

Exclusion criteria

Exclusion Criteria:

Participants with acute or chronic musculoskeletal disorders, cardiovascular diseases, or similar conditions.
Participants with abnormal blood pressure: resting systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg, or those taking antihypertensive medications.
Participants with abnormally high arterial stiffness (within pathological range): brachial-ankle pulse wave velocity (baPWV) >1800 cm/s.
Participants recently taken medications that may affect blood indicators, such as hormones or anti-inflammatory drugs.
Participants with unstable body weight in the past 3 months (fluctuation greater than ±2.5 kg).
Participants currently participating in other intervention studies or those with regular exercise habits in daily life.
Participants who smoke or consume alcohol regularly.

Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Postmenopausal: Periods have stopped for good: usually no period for 12 months in a row without another medical reason, sometimes confirmed by a blood test (FSH).

Study design

Phase: Not applicable
Primary purpose: Prevention
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Single (Outcomes assessor)
Enrollment: 113 participants (actual)

Study arms

Active comparator
AE group
Behavioral: AE group
Active comparator
RE group
Behavioral: RE group
Active comparator
CE group
Behavioral: CE group
Active comparator
CON group
Behavioral: ON group

Interventions

BehavioralAE group
Aerobic exercise
BehavioralRE group
Resistance exercise
BehavioralCE group
Combined exercise
BehavioralON group
No intervention

What researchers measure

Primary outcomes

Flow mediated dilation (FMD)
The change of flow mediated dilation before and after intervention.
Time frame: 12 weeks
Brachial ankle pulse wave velocity (baPWV)
The change of baPWV before and after intervention.
Time frame: 12 weeks
Ankle brachial index (ABI)
The change of ABI before and after intervention.
Time frame: 12 weeks
Carotid intima-media thickness (cIMT)
The change of cIMT before and after intervention.
Time frame: 12 weeks
Systolic blood pressure (SBP)
The change of SBP before and after intervention.
Time frame: 12 weeks
Diastolic blood pressure (DBP)
The change of DBP before and after intervention.
Time frame: 12 weeks
Peak systolic velocity (PSV)
The change of PSV of carotid artery before and after intervention.
Time frame: 12 weeks
End diastolic velocity (EDV)
The change of EDV of carotid artery before and after intervention.
Time frame: 12 weeks
Pulsatility index (PI)
The change of PI of carotid artery before and after intervention.
Time frame: 12 weeks
Resistance index (RI)
The change of RI of carotid artery before and after intervention.
Time frame: 12 weeks
Wall Shear Stress (WSS)
The change of WSS of carotid artery before and after intervention.
Time frame: 12 weeks

Secondary outcomes

Nitric oxide (NO)
The change of serum NO before and after intervention.
Time frame: 12 weeks
Prostacyclin (PGI2)
The change of serum PGI2 before and after intervention.
Time frame: 12 weeks
Endothelin-1 (ET-1)
The change of serum ET-1 before and after intervention.
Time frame: 12 weeks
Angiotensin II (AngII)
The change of serum AngII before and after intervention.
Time frame: 12 weeks
C-Reactive protein (CRP)
The change of serum CRP before and after intervention.
Time frame: 12 weeks
Interleukin-6 (IL-6)
The change of serum IL-6 before and after intervention.
Time frame: 12 weeks
Estrogen
The change of serum estrogen before and after intervention.
Time frame: 12 weeks
Soluble intercellular adhesion molecule-1(sICAM-1)
The change of serum sICAM-1 before and after intervention.
Time frame: 12 weeks
Soluble vascular cell adhesion molecule-1 (sVCAM-1)
The change of serum sVCAM-1 before and after intervention.
Time frame: 12 weeks
Total Cholesterol (TC)
The change of serum TC before and after intervention.
Time frame: 12 weeks
High-density lipoprotein cholesterol (HDL-C)
The change of serum HDL-C before and after intervention.
Time frame: 12 weeks
Low-density lipoprotein cholesterol (LDL-C)
The change of serum LDL-C before and after intervention.
Time frame: 12 weeks
Left ventricular posterior wall thickness at end-diastole (LVPWd)
The change of LVPWd before and after intervention.
Time frame: 12 weeks
Left ventricular posterior wall thickness at end-systole (LVPWs)
The change of LVPWs before and after intervention.
Time frame: 12 weeks
Stroke volume (SV)
The change of SV before and after intervention.
Time frame: 12 weeks
Heart rate (HR)
The change of HR before and after intervention.
Time frame: 12 weeks
Left ventricular ejection fraction (LVEF)
The change of LVEF before and after intervention.
Time frame: 12 weeks
Cardiac output (CO)
The change of CO before and after intervention.
Time frame: 12 weeks
Endothelial Nitric Oxide Synthase (eNOS)
The change of serum eNOS before and after intervention.
Time frame: 12 weeks
Maximal oxygen uptake (VO2max)
The change of VO2max before and after intervention.
Time frame: 12 weeks
Body mass index (BMI)
The change of BMI before and after intervention.
Time frame: 12 weeks
Body fat weight
The change of body fat weight before and after intervention.
Time frame: 12 weeks
Body fat%
The change of body fat% before and after intervention.
Time frame: 12 weeks
Pittsburgh sleep quality index (PSQI)
The change of PSQI before and after intervention.
Time frame: 12 weeks
Food frequency questionnaire (FFQ)
The change of FFQ before and after intervention.
Time frame: 12 weeks
Cluster of Differentiation 14 (CD14) mRNA and Protein Expression
The change of CD14 mRNA and Protein Expression before and after intervention.
Time frame: 12 weeks
Mitogen-activated protein kinase 14 (MAPK14) mRNA
The change of MAPK14 mRNA before and after intervention.
Time frame: 12 weeks
p38 Mitogen-activated protein kinase (p38 MAPK) Protein Expression
The change of p38 MAPK Protein Expression before and after intervention.
Time frame: 12 weeks
Tetraspanin 4 (TSPAN4) mRNA and Protein Expression
The change of TSPAN4 mRNA and Protein Expression before and after intervention.
Time frame: 12 weeks
Nitric Oxide Synthase 3 (NOS3) mRNA and Protein Expression
The change of NOS3 mRNA and Protein Expression before and after intervention.
Time frame: 12 weeks

Study locations

1 site

School of Sports Medicine and Rehabilitation, Beijing Sport University
Beijing, China

Timeline

Tracking since Sep 25, 2026

ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Feb 2025 to primary completion in Jul 2025, 5 months.

Of 733 non-industry interventional studies with no phase under Sedentary Behavior, half reached primary completion within 14 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 31. This study's 5 months is below that.

Counting every sponsor, half of 741 studies reached it within 14 months; a quarter within 6 and three quarters within 31.

How these figures are worked out, and which studies are left out of them.

Registered: Apr 20, 2026
First posted: Apr 24, 2026
StartActual: Feb 15, 2025
Primary completionActual: Jul 30, 2025
CompletionActual: Dec 30, 2025
Last update: Apr 24, 2026

What these dates mean

Start.: When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.: When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.: When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.: Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.

No changes since tracking began. The registry record was last updated on Apr 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT07550829
Lead sponsor: Beijing Sport University
Responsible party: Sponsor
First posted: Apr 24, 2026
Start date: Feb 15, 2025
Primary completion: Jul 30, 2025
Completion: Dec 30, 2025
Last update: Apr 24, 2026

Oversight

FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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