An observational study in Multiple Sclerosis, sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-04-23.
Sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Observational
Individuals aged 18-80 years who have been clinically diagnosed with multiple sclerosis and their caregivers will be included in the study.
Demographic data of the patients, including age, height, weight, and comorbidities, will be recorded. Disease-specific characteristics such as disease duration, presence of incontinence, ambulation status, and presence and severity of pain will be assessed. Functional status of the patients will be evaluated using the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Impact Scale (MSIS). Symptoms related to depression and anxiety in patients will be assessed using the Hospital Anxiety and Depression Scale (HADS).
Subsequently, caregivers of the patients will be evaluated. The severity of insomnia will be assessed using the Insomnia Severity Index (ISI). Symptoms related to anxiety and depression will be evaluated using the Hospital Anxiety and Depression Scale (HADS). Caregiver burden will be assessed using the Zarit Caregiver Burden Scale.
Multiple sclerosis and caregivers
Exclusion Criteria:
No intervention
Zarit Caregiver Burden Scale (Zarit Burden Interview, ZBI)
Caregiver burden will be assessed using the Zarit Caregiver Burden Scale. Higher scores indicate greater caregiver burden.
Time frame: Baseline
Insomnia Severity Index (ISI)
The ISI evaluates the severity of insomnia symptoms. Total scores range from 0 to 28, with higher scores indicating more severe insomnia.
Time frame: Baseline
Hospital Anxiety and Depression Scale - Anxiety Subscale (HADS-A)
Scores range from 0 to 21, with higher scores indicating greater anxiety.
Time frame: Baseline
Hospital Anxiety and Depression Scale - Depression Subscale (HADS-D)
Scores range from 0 to 21, with higher scores indicating greater depressive symptoms.
Time frame: Baseline
Expanded Disability Status Scale (EDSS)
The EDSS evaluates disability in multiple sclerosis patients, ranging from 0 (normal neurological exam) to 10 (death due to MS).
Time frame: Baseline
Multiple Sclerosis Impact Scale (MSIS)
The MSIS assesses the physical and psychological impact of multiple sclerosis on daily life. Higher scores indicate greater impact.
Time frame: Baseline
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Istanbul Physical Medicine Rehabilitation Training and Research Hospital