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RecruitingNCT07538414FONDAUpdated Apr 20, 2026

Investigation of Patients Presenting With Acute Functional Neurological Symptoms

An observational study in Functional Neurological Disorder, sponsored by University Hospital, Basel, Switzerland. Recruiting at 1 site in Switzerland. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2026-04-20.

Sponsored by University Hospital, Basel, Switzerland · Observational

From the registry’s dates

  • Started Mar 2026; still recruiting 7 months later.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
1,000
Ages
16 Years and older
Sex
All
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Study summary

Retrospective Single-center Analysis of Patients Presenting With Acute Neurological Symptoms, Aiming to Characterize the Frequency, Clinical Features, Diagnostic Pathways, and Healthcare Utilization of Patients with Functional Neurological Diseases

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Conditions studied

  • Functional Neurological Disorder

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03

In context

Conversion Disorder

89 studies on the registry are indexed under Conversion Disorder; 34 are open to participants now.

This study's planned enrollment of 1,000 is above the median of 60 across 37 observational studies indexed under Conversion Disorder.

Browse Conversion Disorder studies →

Lead sponsor

University Hospital, Basel, Switzerland is the lead sponsor of 990 studies on the registry; 189 are open to participants now.

Browse University Hospital, Basel, Switzerland studies →

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
16 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients presenting with acute symptoms

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients older than 16 years old presenting as an emergency case to the University Hospital Basel between 1 January 2012 and 31 March 2026
  • with acute neurological symptoms requiring immediate neurological work-up (e.g, acute motor or sensory disturbance, acute speech disorder, acute vestibular disorder, acute cognitive disorder, acute consciousness disorder, acute seizure disorder)
  • and a documented diagnostic evaluation during hospitalization.

Exclusion criteria

Exclusion Criteria:

  • Documented refusal for further use of health related data for research purposes
  • Insufficient documentation to determine diagnosis or clinical course
  • Incomplete or inconsistent datasets compromising valid endpoint determination
  • Younger than 16 years
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
1,000 participants (estimated)
Patient registry
No

Interventions

  • Othercollection of patient data

    collection of patient data

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What researchers measure

Primary outcomes

  1. Frequency of FND

    The primary endpoint is the proportion of patients presenting with acute neurological symptoms who receive a diagnosis or likely differential diagnosis of Functional Neurological Disorder (FND) during their index hospital admission.

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

Secondary outcomes

  1. Secondary Outcomes

    Diagnostic Process Measures (%): Referral patterns and evaluation of alternative or concurrent neurological diagnoses.

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

  2. Secondary Outcomes

    Diagnostic Resource Utilization (%): Clinical examination findings, neuroimaging, neurophysiological testing, and laboratory investigations.

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

  3. Secondary Outcomes

    Healthcare Utilization and Outcomes (%): Discharge destination, readmission, outpatient follow-up, and in-hospital mortality.

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

  4. Secondary Outcomes

    Quality of Care Associations (%) Demographic and clinical variables associated with diagnostic performance and healthcare utilization.

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

  5. Secondary Outcomes

    Comparative Analyses: FND vs Non-FND (%): Differences in diagnostics, resource utilization, escalation of care, and short-term outcomes.

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

  6. Secondary Outcomes

    Subtype Analyses (%): Differences across FND subtypes in presentation, diagnostics, management, and outcomes.

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

  7. Secondary Outcomes

    Time to Definitive Diagnosis (days)

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

  8. Secondary Outcomes

    Length of Hospital Stay (days)

    Time frame: At hospital discharge (index admission), up to 30 days from presentation

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Study locations

1 of 1 sites recruiting
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Mar 2026 (actual). Primary completion is estimated for Dec 2050, 297 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Mar 30, 2026
First posted
Apr 20, 2026
StartActual
Mar 30, 2026
Primary completionEst.
Dec 2050
CompletionEst.
Dec 2050
Last update
Apr 20, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07538414
Lead sponsor
University Hospital, Basel, Switzerland
Responsible party
Urs Fisch (Principal investigator, University Hospital, Basel, Switzerland) — Principal investigator
First posted
Apr 20, 2026
Start date
Mar 30, 2026
Primary completion
Dec 2050 (estimated)
Completion
Dec 2050 (estimated)
Last update
Apr 20, 2026

Study contacts

Urs Fisch, MD PhD
Contact
urs.fisch@usb.ch
+41 61 265 2525

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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