An interventional study of Sciatic Nerve Mobilization in Sciatic Nerve and Lower Extremity Pain, sponsored by Fenerbahce University. Enrolling by invitation at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-07.
Sponsored by Fenerbahce University · Not applicable, Interventional, and Basic science
This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves. The study will be conducted in university students at Fenerbahçe University. Participants will be randomly assigned to either an intervention group or a control group.
Pressure pain threshold (PPT) will be measured using a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves before and after the intervention period. Demographic and clinical information, including age, sex, height, weight, dominant lower extremity, physical activity level, history of lower extremity injury or surgery, neurological or systemic disease, and regular medication use, will also be recorded.
Participants in the intervention group will receive a standardized sciatic nerve mobilization protocol consisting of sliding-type neurodynamic mobilization performed in the supine position, including components of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion in a rhythmic sequence. No intervention will be applied to the control group. The primary purpose of the study is to determine whether sciatic nerve mobilization changes pressure pain threshold values in the tibial and common peroneal nerves compared with no intervention.
This randomized controlled pilot study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial nerve and the common peroneal nerve, in healthy university students. The study will be conducted at Fenerbahçe University.
A total of 34 participants will be included. Eligible participants will be students aged 18 to 30 years at Fenerbahçe University who voluntarily agree to participate and meet the study eligibility criteria. Participants will be randomly assigned to an intervention group or a control group.
Pain perception will be assessed using pressure pain threshold measurements obtained with a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves. Measurements will be performed before and after the study procedure using the same protocol for all participants.
Participants in the intervention group will receive a standardized sliding-type sciatic nerve mobilization protocol performed in the supine position. The mobilization includes coordinated movements of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion to create a sliding effect on the sciatic nerve. The control group will not receive any intervention.
10,054 studies on the registry are indexed under Pain; 1,649 are open to participants now.
This study's planned enrollment of 34 is below the median of 66 across 8,493 interventional studies indexed under Pain.
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You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this group will receive a standardized sliding-type sciatic nerve mobilization. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the intervention.
Other: Sciatic Nerve Mobilization
Participants in this group will receive no intervention. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the study procedure.
A standardized sliding-type sciatic nerve mobilization will be applied in the supine position. The technique includes coordinated hip flexion, knee extension, and ankle dorsiflexion/plantarflexion movements to produce a sliding effect on the sciatic nerve.
Pressure Pain Threshold of the Tibial Nerve
Pressure pain threshold of the tibial nerve will be assessed using a pressure algometer at a standardized anatomical point in the popliteal fossa. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Time frame: Before intervention and immediately after intervention
Pressure Pain Threshold of the Common Peroneal Nerve
Pressure pain threshold of the common peroneal nerve will be assessed using a pressure algometer at a standardized anatomical point around the fibular head/neck region. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.
Time frame: Before intervention and immediately after intervention
Plan to share: No — Individual participant data (IPD) will not be shared because the study involves a small sample from a single university population, and data sharing could increase the risk of participant identification.
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