An interventional study of Phase 1 - Silence (Baseline) and Phase 2 - Happy Mode with Measured Rhythm in Analgesic Effects of Music, sponsored by Rawane El Dimachki. Completed at 1 site in Lebanon. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-07.
Sponsored by Rawane El Dimachki · Not applicable, Interventional, and Supportive care
This study aims to understand whether listening to music can reduce pain and anxiety caused by a cold-temperature stimulus in healthy young adults (n = 30). It also seeks to identify which musical and neurocognitive factors can produce a calming, analgesic (reduce pain), and anxiolytic (reduce anxiety) effect.
The main questions it aims to answer are:
Participants will:
This study aims to deepen our understanding of how musical and neurocognitive elements contribute to the sedative effect of music during care situations, and to support the development of a more precise and personalized musical model for use in dental procedures.
1,190 studies on the registry are indexed under Agnosia; 508 are open to participants now.
This study's enrollment of 40 is below the median of 78 across 1,024 interventional studies indexed under Agnosia.
Browse Agnosia studies →Rawane El Dimachki is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Exclusion Criteria:
All participants undergo eight sequential experimental conditions (phases) of the cold pressor test under different controlled conditions (silence, happy music with measures rhythm, sad music with measured rhythm, happy music with non measured rhythm, sad music with non measured rhythm, their own music, music chosed from a palette).
Behavioral: Phase 1 - Silence (Baseline) · Behavioral: Phase 2 - Happy Mode with Measured Rhythm · Behavioral: Phase 3 - Sad Mode with Measured Rhythm · Behavioral: Phase 4 - Happy Mode with Non-Measured Rhythm · Behavioral: Phase 5 - Sad Mode with Non-Measured Rhythm Type: Behavioral · Behavioral: Phase 6 - Participant-Selected from Predefined Set · Behavioral: Phase 7 - Silence (Post-Exposure) · Behavioral: Phase 8 - Participant's Own Choice
Participants undergo the cold pressor test in complete silence without any auditory stimulation. This baseline condition serves as a control for comparison with subsequent music conditions.
Participants undergo the cold pressor test while listening to music characterized by a happy emotional mode and a regular, measured rhythmic structure.
Participants undergo the cold pressor test while listening to music characterized by a sad emotional mode and a regular, measured rhythmic structure.
Participants undergo the cold pressor test while listening to music characterized by a happy emotional mode and a non-measured (free) rhythmic structure.
Participants undergo the cold pressor test while listening to music characterized by a sad emotional mode and a non-measured (free or irregular) rhythmic structure.
Participants undergo the cold pressor test while listening to a piece of music selected by themselves from a predefined set of musical options provided by the researchers.
Participants undergo the cold pressor test in silence following prior experimental conditions. This control condition is included to assess potential changes in pain tolerance over time and to distinguish music effects from habituation or adaptation.
Optional intervention : participants undergo the cold pressor test while listening to a self-selected piece of music of their own choosing.
Pain Tolerance Duration
Pain tolerance will be measured as the total duration (in seconds) that participants are able to keep their hand immersed in cold water during each phase. A stopwatch will be used to record immersion time.
Time frame: Within a single study session (approximately 90 minutes); measured (from hand immersion to withdrawal) during 8 distinct cold pressor test phases, with each phase lasting up to a maximum of 4 minutes.
Reaction Time to Pain
The time elapsed between the onset of hand immersion in cold water and the participant's first reported perception of pain will be recorded. This measure provides insight into how musical conditions may influence the temporal perception of pain onset.
Time frame: Within a single study session (approximately 90 minutes); measured from initial hand immersion to the onset of pain perception during each of the 8 distinct cold pressor test phases (each phase lasting a maximum of 4 minutes).
Pain Intensity
Pain intensity is assessed using a Visual Analog Scale (VAS), where participants rate their perceived pain during each phase of the cold pressor test. The scale ranges from 0 to 10, where 0 represents "no pain" and 10 represents "the worst possible pain."
Time frame: Within a single study session (approximately 90 minutes); assessed continuously during 8 distinct cold pressor test phases, with each phase lasting up to 4 minutes.
Qualitative Feedback
A study-specific, 15-item multi-dimensional questionnaire designed to evaluate participants' subjective experience across: 1. Pain and Anxiety Perception (e.g., categorical rating from "Mild" to "Intense"). 2. Emotional Response to Music (e.g., 5-point scale from "Very Relaxed" to "Anxious"). 3. Music Preference and Familiarity (e.g., selection of preferred musical mode). 4. Cumulative Experience (e.g., comparative assessment of pain tolerance). For the scaled items (such as Question 7: "Effect of music on pain level"), scores range from 1 (No effect) to 5 (Very significant effect), where higher scores indicate a better outcome (greater perceived music effectiveness). Qualitative open-ended responses regarding emotional tone and rhythm are collected to provide contextual depth to the physiological data.
Time frame: Within a single study session (approximately 90 minutes); assessed after each of the 8 cold pressor test phases (each phase lasting a maximum of 4 minutes) and at the conclusion of the session.
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This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Rawane El Dimachki