CClinicalTrials.gg
Not yet recruitingNCT07507487Updated Apr 2, 2026

TNFAIP3 Gene Expression in Ankylosing Spondylitis and Psoriatic Arthritis Patients and Its Relation to Disease Activity

An interventional study of Detection of TNFAIP3 gene expression by real time PCR. in Ankylosing Spondylitis and Psoriatic Arthritis Patients, sponsored by Asmaa Hassan mohamed Abdel Mawjoud. Not yet recruiting. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-02.

Sponsored by Asmaa Hassan mohamed Abdel Mawjoud · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
110
Allocation
Randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

  1. Identify gene expression of TNFAIP3 in ankylosing spondylitis and psoriatic arthritis patients.
  2. Detect relation between TNFAIP3 and disease activity.

Inclusion criteria:

  1. Patients diagnosed with ankylosing spondylitis according to Modified New York classification criteria 1984 (10).
  2. Patients diagnosed with psoriatic arthritis (PsA patients (age ≥18 years) who fulfilled the CASPAR classification criteria for PsA 2010) (11).

    b. Exclusion criteria: Patients with erythrodermic or pustular psoriasis, pregnant and lactating females, patients with autoimmune diseases e.g. systemic lupus erythematosus, or major systemic diseases, and patients receiving any immunosuppressive drug will be excluded from the study.

02

Conditions studied

  • Ankylosing Spondylitis and Psoriatic Arthritis Patients
03

In context

Spondylitis, Ankylosing

498 studies on the registry are indexed under Spondylitis, Ankylosing; 89 are open to participants now.

This study's planned enrollment of 110 is above the median of 84 across 275 interventional studies indexed under Spondylitis, Ankylosing.

Browse Spondylitis, Ankylosing studies →

Lead sponsor

Asmaa Hassan mohamed Abdel Mawjoud is the lead sponsor of 2 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

- 1. Patients diagnosed with ankylosing spondylitis according to Modified New York classification criteria 1984.

2. Patients diagnosed with psoriatic arthritis (PsA patients (age ≥18 years) who fulfilled the CASPAR classification criteria for PsA 2010)

Exclusion criteria

Exclusion Criteria:

  • Patients with erythrodermic or pustular psoriasis, pregnant and lactating females, patients with autoimmune diseases e.g. systemic lupus erythematosus, or major systemic diseases, and patients receiving any immunosuppressive drug will be excluded from the study.
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Randomized
Intervention model
Sequential assignment
Masking
Double (Participant, Care provider)
Enrollment
110 participants (estimated)

Study arms

  • Experimental
    ankylosing spondylitis

    Diagnostic Test: Detection of TNFAIP3 gene expression by real time PCR.

  • Experimental
    psoriatic arthritis patients

    Diagnostic Test: Detection of TNFAIP3 gene expression by real time PCR.

Interventions

  • Diagnostic testDetection of TNFAIP3 gene expression by real time PCR.

    Detection of TNFAIP3 gene expression by real time PCR.

06

What researchers measure

Primary outcomes

  1. Detection of TNFAIP3 gene expression. Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the axial bone and sacroiliac joints. Its etiology involves genetic, environmental variables and demographic factors .

    Time frame: 18 months

Secondary outcomes

  1. Detect relation between TNFAIP3 and ankylosing spondylitis apsoriatic arthritis activity. detection of TNFAIP3 gene expression by real time PCR will be done for every subject.

    Time frame: 20 months

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 2, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07507487
Lead sponsor
Asmaa Hassan mohamed Abdel Mawjoud
Collaborators
Assiut University
Responsible party
Asmaa Hassan mohamed Abdel Mawjoud (asmaa hassan mohamed, Assiut University) — Sponsor-investigator
First posted
Apr 2, 2026
Start date
Apr 2026 (estimated)
Primary completion
Dec 2028 (estimated)
Completion
Jul 2029 (estimated)
Last update
Apr 2, 2026

Study contacts

asmaa mohmed, master
Contact
a94asmaa@gmail.com
01024850070

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion