An interventional study of GASTROCNEMIUS MYOFASCIAL RELEASE and sham Gastrocnemius MYOFASCIAL RELEASE in Knee Osteoarthritis, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to female participants aged 45 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-04-02.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to determine whether gastrocnemius myofascial release is effective in reducing pain and improving physical function in females with knee osteoarthritis.
The main question this study aims to answer are:
3,302 studies on the registry are indexed under Osteoarthritis, Knee; 608 are open to participants now.
This study's planned enrollment of 30 is below the median of 70 across 2,731 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
A diagnosis of knee osteoarthritis was made when knee pain is present, plus Osteophytes on radiographs, plus at least 1 of the following 3:
Exclusion Criteria:
GM MFR and TrP pressure release with a combination of manual physical therapy (knee mobilization), supervised exercise (riding a stationary bike, muscle strengthening exercises for the hip and knee, and self-stretching of lower limb muscles), and TENS
Procedure: GASTROCNEMIUS MYOFASCIAL RELEASE
sham GM MFR with a combination of manual physical therapy (knee mobilization), supervised exercise (riding a stationary bike, muscle strengthening exercises for the hip and knee, and self-stretching of lower limb muscles), and TENS
Procedure: sham Gastrocnemius MYOFASCIAL RELEASE
Gastrocnemius MFR Procedures : * Technique 1: With the elbow flexed to 90◦ and take up a contact in the Tendo Achilles. Establish a line of tension in a superior direction. * Technique 2: with the index and middle fingers of each hand to take up a contact on the tendons of the GM at the epicondyles of the femur. Establish a line of tension in an inferior direction. * Technique 3: With the index, middle and ring fingers of each hand to get into the medial and lateral aspects of the calcaneus . The release begins proximally. * (5 minutes× 1 repetition) for the three technique * Gastrocnemius TrP pressure release is repeated for 90 seconds (usually 3 repetitions). * Anterior glide \& Posterior glide (grade IV) * Riding a stationary bike for 5 minutes * Quadriceps set exercise * Terminal knee extension * Step-up exercises for 30 seconds * Lateral Step-up for 30 seconds. * Self-stretching of Hamstring, Rectus femoris ,and Calf muscles. * TENS for 20 minutes
Also known as: Gastrocnemius MFR
Patient position: Prone, with feet off the end of the table to allow for adequate dorsiflexion. Therapist's position:, facing toward the feet while standing at the patient's side, at around mid-thigh level for techniques. Technique: one hand is positioned at the attachments of the GM at the epicondyles of the femur, and the other at the Achilles tendon without applying significant pressure or tissue deformation. Mimic the hand movements of real myofascial release (e.g., slow stroking, superficial gliding) but avoid: Deep pressure, Skin stretch, and Muscle compression. * Anterior glide \& Posterior glide (grade IV) * Riding a stationary bike for 5 minutes * Quadriceps set exercise * Terminal knee extension * Step-up exercises for 30 seconds * Lateral Step-up for 30 seconds. * Self-stretching of Hamstring, Rectus femoris ,and Calf muscles. * TENS for 20 minutes
Also known as: Placebo Gastrocnemius Myofascial Release
Pain during rest and single leg squat (Visual analogue scale)
Participants are instructed to draw a vertical mark on the line indicating their pain level during rest and single leg squat -single leg squat: The Participants stand on the limb being evaluated, with the other leg lifted off the ground so that the hip is flexed to approximately 45 degrees and the knee to approximately 90 degrees. The Participants' shoulders is forward flexed to 90 degrees with the elbows in full extension and the hands clasp together in front. The Participants are forward flexed to squat down until feeling pain and discomfort and return to the start position.
Time frame: pain is measured at baseline at the first session and reassessed at the end of the second week, and at the end of four weeks.
Physical function (40 m fast-paced walk test )
\- 40MFPW : The participants walk as quickly and safely as possible on a 10-m walkway, turn around a cone placed 2 m beyond each end of the walkway, and return for a total distance of 40 m.
Time frame: Physical function is measured at baseline at the first session and reassessed at the end of the second week, and at the end of four weeks.
Physical function (the 30-s chair-stand test)
\- 30sCST : The participants stand up completely from a sitting position from an unarmed and straight-backed chair ; and then completely back down until they are completely on the seat. The maximum number of chair-stand repetitions completed in 30 seconds is recorded.
Time frame: Physical function is measured at baseline at the first session and reassessed at the end of the second week, and at the end of four weeks.
Physical function (a stair-climb test )
\- 9-s SCT: The participants ascend and descend nine stairs as quickly as possible but in a safe manner. The time for the participants to complete the ascending and descending tasks is recorded.
Time frame: Physical function is measured at baseline at the first session and reassessed at the end of the second week, and at the end of four weeks.
Foot posture (foot posture index 6)
FPI-6 is considered a quick, easy, inexpensive, and multi-segmental clinical quantification tool, which can assess the posture of the foot. FPI-6 score consisted of six items: (1) Talar head palpation, (2) curves above and below the lateral malleolus, (3) Talonavicular joint bulging (4) Calcaneal frontal plane position, (5) Medial longitudinal arch height and congruence (6) Forefoot abduction or adduction. the participant are in a standing, relaxed stance position, arms by the side, and looking straight ahead. Then, take several steps in place before settling into a comfortable stance position. The assessor needs to be able to move around the patient during the assessment and to have uninterrupted access to the posterior aspect of the leg and foot. Approximately two minutes for the assessment to be conducted. the total score ranging from -12 to +12. * Pronated postures are given a positive value * Supinated features are given a negative value * neutral foot score around zero
Time frame: Foot posture is measured at baseline at the first session and reassessed at the end of the second week, and at the end of four weeks.
Knee Disability (Arabic version of Algofunctional index of lequense)
The Lequesne Algofunctional Index is a 10-question interview format questionnaire that was designed as a single unit. These 10 parameters are divided into three sections to assess 'pain or discomfort' (L1), 'maximum distance walked' (L2), and 'activities of daily living' (L3). The Lequesne index directly aggregates symptoms and function, which results in a single global index score ranging from 0 (no pain, no disability) to 24 (maximum pain, stiffness, and disability).
Time frame: Knee Disability is measured at baseline at the first session and reassessed at the end of the second week, and at the end of four weeks.
Plan to share: No
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Cairo University