An interventional study of 8-Week Unilateral Strength and Balance Program for the Less Affected Leg in Older Adults With Bilateral Knee Osteoarthritis and 8-Week Unilateral Balance Training Program for the Less Affected Leg in Older Adults With Bilateral Knee Osteoarthritis in Knee Osteoarthritis (OA), sponsored by University of Zagreb. Not yet recruiting at 1 site in Croatia. Open to participants aged 60 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-03-24.
Sponsored by University of Zagreb · Not applicable, Interventional, and Treatment
Kinesitherapy is one of the main tools in the rehabilitation of knee osteoarthritis, but is often limited due to pain, reduced functionality, and fear of falling in older adults. This study will, through three sub-studies, examine the effects of unilateral training programs on strength, movement control, balance, and pain in the contralateral leg, as well as on functionality, fall risk, and kinesiophobia in older adults with bilateral knee osteoarthritis through three sub-studies. A total of 45 participants (aged 60-80 years) with bilateral knee osteoarthritis will be randomly assigned to one of three groups: 1. combined unilateral strength and balance training; 2. unilateral balance training; 3. unilateral strength training. Strength will be measured with maximal voluntary contraction, balance using a single leg stance test on an unstable surface, movement control with an active joint position reproduction test, and functionality using the six-minute walk test and the Western Ontario and McMaster Osteoarthritis Index questionnaire. Pain will be assessed with the Visual Analog Scale and the Intermittent and Constant Osteoarthritis Pain questionnaire, fall risk with the Timed Up and Go test and the Falls Efficacy Scale-International questionnaire, and kinesiophobia using the TAMPA questionnaire. This study will expand knowledge on cross-transfer and its effects on symptoms in the rehabilitation of older adults with bilateral knee osteoarthritis.
This research is a part of a doctoral thesis conducted under the supervision of assoc. prof. Tatjana Trošt, PhD.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 45 is below the median of 68 across 2,714 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →University of Zagreb is the lead sponsor of 71 studies on the registry; 14 are open to participants now.
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Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: 8-Week Unilateral Strength and Balance Program for the Less Affected Leg in Older Adults With Bilateral Knee Osteoarthritis
Other: 8-Week Unilateral Balance Training Program for the Less Affected Leg in Older Adults With Bilateral Knee Osteoarthritis
Other: 8-Week Unilateral Strength Training Program for the Less Affected Leg in Older Adults With Bilateral Knee Osteoarthritis
Participants perform unilateral exercises with the less affected leg, combining strength and balance training. Each session lasts 50 minutes, including warm-up, main exercises (15-20 min), and relaxation. The program consists of 24 sessions over 8 weeks.
Participants perform unilateral balance exercises with the less affected leg. Each 50-minute session includes warm-up, 15-20 minutes of main balance exercises, and relaxation. The program lasts 8 weeks with 24 sessions.
Participants perform unilateral strength exercises with the less affected leg. Each 50-minute session includes warm-up, 15-20 minutes of main strength exercises, and relaxation. The program lasts 8 weeks with 24 sessions.
Change from baseline in balance performance in older adults with bilateral knee osteoarthritis after 8 weeks of unilateral strength and/or balance training across all three intervention groups
Time frame: From baseline (pre-intervention) to the end of the 8-week training program
This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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University of Zagreb