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RecruitingNCT07484516Updated Jul 20, 2026

Effects of Eccentric Exercises Along With Muscle Energy Technique in Lateral Epicondylitis

An interventional study of Eccentric exercise along with muscle energy technique and Muscle energy technique in Lateral Epicondylitis, sponsored by Riphah International University. Recruiting at 1 site in Pakistan. Open to participants aged 20 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-07-20.

Sponsored by Riphah International University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Mar 2026; still recruiting 6 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
66
Allocation
Randomized
Ages
20 Years to 50 Years
Sex
All
01

Study summary

This study is intended to find the effects of Eccentric exercises along with muscle energy technique (MET) on pain, functional disability, range of motion and grip strength in Lateral Epicondylitis. For this trial, participants will be enrolled with their consent after assessing on basis of inclusion \& exclusion criteria from orthopedic workshop, Jinnah post graduate medical center Karachi. Total of 66 participants will be recruited and will be equally randomized into three groups consisting of 22 participants in each group. They would recruit into either Eccentric exercise (EE) along with MET group (group A) or MET group (group B) or EE group (group C). Participants will be allocated to intervention by sealed envelope method and will undergo a total of 8 treatment sessions within 2 weeks. Baseline assessment will carry out before treatment on 1st session and follow-up assessment on 8th session after treatment through tool named as Numeric Pain-Rating Scale (NPRS), Patient Rated Tennis Elbow Evaluation (PRTEE), Goniometer and Handheld dynamometer.

Read the detailed description

Lateral epicondylitis is one of the commonest reason of lateral elbow pain that affects 1-3% of the general population of middle-aged adults. A large population-based study of United States estimated its incidence as 3.4 cases per 1000 person annually with peak rates for 40-60 years old age group ranging between 7% and 10%.

Lateral epicondylitis (LE) or tennis elbow is simply a myotendinosis of the forearm extensor muscles that frequently associate with overuse injury due to repetitive strain by activities which impose excessive loads on common extensor tendinous origin at lateral epicondyle. Commonly this has been reported in those who engaged in activities which consist of repetitive wrist extension, radial deviation, gripping and/or forearm supination.

It leads to localized pain and tenderness at lateral epicondyle and along with the common extensor mass of the elbow making seemingly simple daily activities more difficult. This exaggerated with activities involving resisted wrist extension, middle finger extension, and forearm supination with extended elbow. The most common functional concern in LE is weak grip and restricted supination.

A vast number of physical therapy treatments such as different manual therapy techniques, exercise programs and modalities have been used. However eccentric training and manual therapy are the two most commonly used and beneficial physiotherapeutic treatment strategies.

Eccentric exercises have been suggested as first line treatment approach in conservative treatment as it improves overall function by lengthening the musculotendinous unit with low intensity load. It promotes healing and remodeling to increase collagen production and reduce pain by inhibiting pain neural pathways. Muscle energy technique (MET), a gentle manual therapy, is effective in addressing both myofascial issues and articular restrictions. It involves a patient's muscle contractions in a controlled position and direction against therapist's counterforce. Recently, international evidence supported its use in LE as a suitable intervention in this pathology and highlight its potential in reducing pain and improving grip and finger strength, and functionality in addition to home stretching and strengthening exercise.

Available literature in targeted population mainly evaluated effects of MET with other treatment techniques like corticosteroids, dry needling, movement with mobilization (MWM), friction massage etc. However, there is very limited literature available on using MET with eccentric exercise as a multimodal treatment for lateral epicondylitis which can point out whether using these two as a combination has better efficacy than alone. This manual therapy technique in combination of eccentric exercises, which has not been extensively studied in the context of lateral epicondylitis, can potentially enhance the therapeutic effects and provide new insights into the treatment and give more effective and tolerable strategy. So, the goal of this trial is to find effects of eccentric exercise along with MET as combined therapy in treating Lateral epicondylitis.

02

Conditions studied

  • Lateral Epicondylitis

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Keywords

  • lateral epicondylitis
  • Muscle energy technique
  • eccentric exercise
03

In context

Tennis Elbow

284 studies on the registry are indexed under Tennis Elbow; 60 are open to participants now.

This study's planned enrollment of 66 is above the median of 50 across 253 interventional studies indexed under Tennis Elbow.

Browse Tennis Elbow studies →

Lead sponsor

Riphah International University is the lead sponsor of 2,133 studies on the registry; 633 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Subacute \& chronic patients
  • Participants diagnosed with lateral epicondylitis based on
  • Pain local to the lateral epicondyle reproduced with palpation.
  • Positive Mill's test and Cozen's test and/or Maudsley's test
  • Patient's willingness in participation in this study.

Exclusion criteria

Exclusion Criteria:

  • Any recent history of fracture /surgery
  • Acute patients
  • Peripheral nerve entrapment like radial tunnel syndrome
  • Cervical radiculopathy
  • Instability of joint
  • Corticosteroid injection within 3- 6 months
  • Neurological impairments
  • Cardiovascular diseases
  • Osteoporosis
  • Local infection
  • Malignancy
  • Congenital /structural anomalies
  • Systemic illness affecting joint function like Rheumatoid arthritis, psoriatic arthritis etc.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
66 participants (estimated)

Study arms

  • Experimental
    Group A: Eccentric exercise along with muscle energy technique

    Pulsed Ultrasound for 10 minutes, eccentric exercise and muscle energy technique for 8 sessions within 2 weeks.

    Other: Eccentric exercise along with muscle energy technique

  • Experimental
    Group B: Muscle energy technique

    Pulsed Ultrasound for 10 minutes and muscle energy technique for 8 sessions within 2 weeks.

    Other: Muscle energy technique

  • Experimental
    Group C: Eccentric exercise

    Pulsed Ultrasound for 10 minutes and eccentric exercise for 8 sessions within 2 weeks.

    Other: Eccentric Exercise

Interventions

  • OtherEccentric exercise along with muscle energy technique

    For Eccentric Exercise, patient be in sitting position with full elbow extension, forearm pronation, and maximum wrist extension. The patient will be asked to slowly lower the wrist with 0.5 or 1 kg weight into flexion for a count of 30. Non-affected hand will be used to return the wrist to maximum extension again. 3 sets of 10 repetitions / session and 1 minute rest/set For MET, patient's affected forearm will be stabilized with 90 degrees flexed elbow. The mobilizing hand will hold the wrist and move into the supination until resistance or discomfort is detected. Then the patient will gently pronate against resistance for 5 seconds. Then with a relaxation phase of 5 seconds the therapist will stretch gently to re-position the forearm into a new supination barrier or until resistance will be met for several seconds (20-30 sec). No. of each isometric contraction in a single session will be 5 times. Pulsed mode ultrasound therapy will be given at frequency of I MHz for 10 minutes.

  • OtherMuscle energy technique

    For MET, patient's affected forearm will be stabilized with elbow 90 degrees flexed. The mobilizing hand will hold the wrist and move into the supination until resistance or discomfort is detected. Then the patient will gently pronate against resistance for 5 seconds. Then with a relaxation phase of 5 seconds the therapist will stretch gently to re-position the forearm into a new supination barrier or until resistance will be met for several seconds (20-30 sec). No of each isometric contraction in a single session will be 5 times. Pulsed mode ultrasound therapy will be given at frequency of I MHz for 10 minutes.

  • OtherEccentric Exercise

    For Eccentric Exercise Patient will be in sitting position with full elbow extension, forearm pronation, and maximum wrist extension. Then the patient will be asked to slowly lower wrist with 0.5 or 1 kg weight into flexion for a count of 30. Then they will use the non-affected hand to return the wrist to maximum extension again. 3 sets of 10 repetitions / session and 1 minute rest/set. Pulsed mode ultrasound therapy will be given at frequency of I MHz for 10 minutes.

06

What researchers measure

Primary outcomes

  1. Numeric Pain Rating Scale

    Changes from Baseline pain values will be taken with the help of Numeric Pain Rating Scale measures level of pain. Scoring is done by selecting a point from zero to ten as the current level of pain. Zero means minimum pain and 10 denotes maximum pain.

    Time frame: 2nd Week

Secondary outcomes

  1. Patient Rated Tennis Elbow Evaluation Scale

    Changes from Baseline functional disability value will be taken with the help of Patient Rated Tennis Elbow Evaluation Scale. The PRTEE, a 15-item self-reported questionnaire, designed to measure patient's perceived pain and disability in Lower Extremity. It consists of 5 items on pain scale, 10 items on function scale.

    Time frame: 2nd Week

  2. Pain-free grip strength

    Changes from Baseline pain-free grip strength will be measured by hand-held dynamometer (in Kg). The amount of force that a patient can generate before any pain will be measured using a handgrip dynamometer and the mean of 3 successive trials will be used.

    Time frame: 2nd Week

  3. Range of Motion

    Changes from Baseline range of motion of wrist extension /flexion and forearm pronation/ supination will be taken with the help of universal goniometer.

    Time frame: 2nd Week

07

Study locations

1 of 1 sites recruiting
  • Jinnah Post Graduate Medical Center (Orthopedic Workshop)
    Karachi, Sindh 75510, Pakistan
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07484516
Lead sponsor
Riphah International University
Responsible party
Sponsor
First posted
Mar 20, 2026
Start date
Mar 20, 2026
Primary completion
Jul 15, 2026 (estimated)
Completion
Jul 20, 2026 (estimated)
Last update
Jul 20, 2026

Study contacts

Dr. Imran Amjad, PT, PhD
Contact
imran.amjad@riphah.edu.pk
03324390125
Dr. Muhammad Affan Iqbal, PT, PhD*
principal investigator · Riphah International university, Islamabad
Dr. Saba Ramzan, PT, MSPT
principal investigator · Riphah International University, Islamabad

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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