An interventional study of 3-D printed overdenture and Conventional overdenture in Ectodermal Dysplasia, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to participants aged 10 Years to 35 Years. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Ectodermal dysplasia is a rare inherited condition that affects structures derived from the ectoderm, including teeth, skin, hair, and sweat glands. Dental findings are often severe and include missing or malformed teeth and poorly developed jaw ridges. These abnormalities can significantly affect chewing, speech, facial appearance, and quality of life, especially in children and young adults. Removable dentures, particularly overdentures when some teeth are present, are commonly used to restore function and appearance in these patients because they are conservative and cost-effective. However, conventional acrylic dentures may show dimensional changes during processing, which can lead to poor denture fit, reduced retention, and lower patient satisfaction. Three-dimensional (3-D) printed dentures are a newer digital fabrication method that may reduce material shrinkage and improve denture adaptation. Despite these potential advantages, clinical evidence comparing 3-D printed and conventional overdentures in patients with ectodermal dysplasia remains limited, highlighting the need for well-designed clinical studies.
The purpose of this study is to compare patient satisfaction and denture base adaptation between 3-D printed maxillary overdentures and conventional acrylic maxillary overdentures in patients with ectodermal dysplasia.
Ectodermal dysplasia patients suffer from partial anodontia, the reduced number of teeth leads to decreased ridge development and reduced surface area of denture which negatively affects the denture adaptation. Conventionally constructed dentures are well accepted but have high polymerization shrinkage which affects denture adaptation. 3D printed dentures offer less polymerization shrinkage when compared to conventional dentures. Clinical studies that investigated digitally manufactured, especially 3D printed, dentures in ectodermal dysplasia patients and their impact on patient satisfaction and denture adaptation are very scarce in dental literature.
10 studies on the registry are indexed under Ectodermal Dysplasia; 6 are open to participants now.
Browse Ectodermal Dysplasia studies →Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
Pathological changes of residual ridges as recurrent or persistent ulcers, osteomyelitis and infections.
4. Patients with medical or psychological conditions as physical disability or mental retardation that hinder cooperation in the follow up visits and answering the questionnaires.
Device: 3-D printed overdenture
Device: Conventional overdenture
Overdenture is constructed using 3 -D printing technology not conventional processing of acrylic resin
overdentures will be constructed using Conventional acrylic processing method
Patient satisfaction
Patient satisfaction will be measured using patient satisfaction questionnaire in ordinal scale. It uses a 5- point Likert scale to give a removable denture satisfaction index.
Time frame: after 1 week and after 3 months after delivery of each denture
Denture adaptation
Denture adaptation will be measured using surface matching software in deviation values. Unit is µm.
Time frame: on delivery day and after 3 months of each denture delivery
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