An interventional study of Evidence-Based Nursing Guideline for Children with Diabetic Ketoacidosos in Diabetic Ketoacidosis, sponsored by Hawler Medical University. Completed at 1 site in Iraq. Open to participants aged 6 Years to 16 Years. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by Hawler Medical University · Not applicable, Interventional, and Treatment
Diabetic ketoacidosis (DKA) is a serious and potentially life-threatening complication of diabetes mellitus in children and requires timely and structured management to prevent morbidity and mortality. Inconsistency in clinical practice and delayed recognition of complications may negatively affect patient outcomes. Evidence-based clinical nursing guidelines can improve the quality and consistency of care provided to children with DKA.
This study aimed to assess the impact of an evidence-based nursing guideline on clinical outcomes among children diagnosed with diabetic ketoacidosis. A quasi-experimental study design was used, including two groups: a control group receiving routine hospital care and an intervention group receiving care based on an evidence-based nursing guideline.
The guideline included structured nursing assessment, continuous monitoring of vital signs and neurological status, blood glucose monitoring, fluid balance monitoring, and early detection and management of complications. Clinical outcomes including blood glucose level, blood pH, neurological status, and duration of hospital stay were compared between the control and intervention groups.
Diabetic ketoacidosis is one of the most common acute complications of diabetes mellitus in pediatric patients and remains a major cause of morbidity and hospital admission among children with diabetes. Effective management requires careful monitoring of metabolic status, fluid therapy, insulin administration, and early detection of complications such as cerebral edema and electrolyte imbalance.
Evidence-based nursing practice plays an essential role in improving the quality of care and patient safety during the management of pediatric diabetic ketoacidosis. Implementation of standardized clinical nursing guidelines can enhance clinical decision-making, improve monitoring of patients, and promote early identification of complications.
This study was conducted to assess the effectiveness of implementing an evidence-based clinical nursing guideline on clinical outcomes among children diagnosed with diabetic ketoacidosis. A quasi-experimental study design was used. Children admitted with diabetic ketoacidosis were divided into a control group receiving routine hospital management and an intervention group receiving care according to an evidence-based nursing guideline.
The guideline included structured monitoring of vital signs, neurological assessment using the Glasgow Coma Scale, frequent blood glucose monitoring, fluid balance monitoring, electrolyte monitoring, and nursing interventions aimed at early detection and prevention of complications.
Clinical outcomes evaluated in this study included blood glucose level, blood pH level, neurological status, and length of hospital stay. The findings of this study are expected to provide evidence regarding the effectiveness of structured nursing guidelines in improving the management and clinical outcomes of pediatric patients with diabetic ketoacidosis.
80 studies on the registry are indexed under Diabetic Ketoacidosis; 15 are open to participants now.
This study's enrollment of 60 is close to the median of 59 across 46 interventional studies indexed under Diabetic Ketoacidosis.
Browse Diabetic Ketoacidosis studies →Hawler Medical University is the lead sponsor of 56 studies on the registry; 6 are open to participants now.
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Exclusion Criteria:
Children with diabetic ketoacidosis who received routine hospital management according to standard hospital protocol without implementation of the evidence-based nursing guideline.
Children with diabetic ketoacidosis who received care according to an evidence-based clinical nursing guideline including structured monitoring of vital signs, neurological assessment, blood glucose monitoring, fluid balance monitoring, and early detection and management of complications.
Other: Evidence-Based Nursing Guideline for Children with Diabetic Ketoacidosos
Implementation of an evidence-based clinical nursing guideline for the management of children with diabetic ketoacidosis. The guideline includes structured nursing assessment, continuous monitoring of vital signs and neurological status using the Glasgow Coma Scale, frequent blood glucose monitoring, fluid balance monitoring, electrolyte monitoring, and nursing interventions aimed at early detection and management of complications during DKA treatment.
Resolution Time of Diabetic ketoacidosis
Time required for resolution of diabetic ketoacidosis measured from hospital admission until normalization of metabolic parameters including blood glucose level, blood pH, and serum bicarbonate according to standard pediatric DKA management criteria.
Time frame: From the time of hospital admission until normalization of metabolic parameters indicating resolution of diabetic ketoacidosis, assessed up to 48 hours.
Blood glucose level
Change in blood glucose level during treatment of DKA, unitl return to normal standard level.
Time frame: From hospital admission to 48 hours after initiation of treatment
Length of hospital stay
Total duration of hospital stay measured in days from admission until discharge of child to home.
Time frame: From hospital admission until hospital discharge, with follow-up assessment conducted up to 2 months after discharge
Plan to share: No — ndividual participant data collected during the study will not be publicly shared due to institutional policies and ethical considerations related to patient confidentiality. Aggregated results will be reported in publications and academic reports.
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Hawler Medical University