An interventional study of Caffeine and taurine in Anaerobic Performance Neuromuscular Performance Cognitive Performance, sponsored by Ankara University. Completed at 1 site in Turkey (Türkiye). Open to male participants aged 18 Years to 25 Years. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by Ankara University · Not applicable, Interventional, and Other
This study aims to investigate the effects of low-dose caffeine and taurine, administered separately and in combination, on anaerobic, neuromuscular, and cognitive performance. The study is designed as a randomized, double-blind, placebo-controlled crossover trial involving trained man participants. Each participant will complete experimental sessions under different supplementation conditions, including caffeine, taurine, their combination, and placebo. Performance outcomes will include anaerobic power, neuromuscular performance, and cognitive function assessments. The findings will help clarify whether the combined ingestion of caffeine and taurine produces synergistic performance effects compared with isolated supplementation.
Caffeine and taurine are commonly consumed ingredients in coffee and energy drinks and are frequently used as ergogenic aids to enhance physical and cognitive performance. Although both compounds have been widely investigated individually, evidence regarding their combined effects remains limited and inconsistent. Understanding whether caffeine and taurine produce synergistic or additive effects is important for clarifying their role in sports performance and supplementation strategies.
The present study is designed as a randomized, double-blind, placebo-controlled crossover trial to examine the isolated and combined effects of low-dose caffeine and taurine on anaerobic, neuromuscular, and cognitive performance in trained individuals. Participants will complete multiple experimental sessions under different supplementation conditions, including caffeine, taurine, their combination, and placebo. During each session, participants will undergo standardized performance assessments to evaluate anaerobic power, neuromuscular performance, and cognitive function. The crossover design allows each participant to serve as their own control, minimizing inter-individual variability. The findings of this study may provide further insight into the potential synergistic effects of caffeine and taurine supplementation on performance outcomes.
Ankara University is the lead sponsor of 312 studies on the registry; 68 are open to participants now.
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Exclusion Criteria:
Participants receive caffeine at a dose of 2 mg/kg body mass in capsule form 60 minutes prior to the performance testing session. Anaerobic, neuromuscular, and cognitive performance outcomes are assessed following supplementation.
Dietary Supplement: Caffeine · Dietary Supplement: Placebo
Participants receive taurine at a dose of 10 mg/kg body mass in capsule form 60 minutes prior to the performance testing session. Anaerobic, neuromuscular, and cognitive performance outcomes are assessed following supplementation.
Dietary Supplement: taurine · Dietary Supplement: Placebo
Participants receive a combination of caffeine (2 mg/kg) and taurine (10 mg/kg) in capsule form 60 minutes prior to the performance testing session. Performance assessments include anaerobic, neuromuscular, and cognitive outcomes.
Dietary Supplement: Caffeine + Taurine
Participants receive a placebo capsule containing maltodextrin (300 mg) 60 minutes prior to the performance testing session. The same performance tests are administered to allow comparison with the supplementation conditions.
Dietary Supplement: Placebo
Caffeine administered at a dose of 2 mg/kg body mass in capsule form, 60 minutes prior to performance testing.
Also known as: CAF
Taurine administered at a dose of 10 mg/kg body mass in capsule form, 60 minutes prior to performance testing.
Also known as: TAU
Combined supplementation of caffeine (2 mg/kg) and taurine (10 mg/kg) administered 60 minutes prior to testing.
Also known as: CAF+TAU
Placebo capsule containing maltodextrin (300 mg) administered 60 minutes prior to testing.
Also known as: PLA
Anaerobic Power
Anaerobic power measured during the Wingate Anaerobic Test following supplementation conditions (caffeine, taurine, caffeine + taurine, and placebo).
Time frame: 60 minutes after supplementation
Neuromuscular Performance
Neuromuscular performance assessed using handgrip strength measured with a hand dynamometer following supplementation.
Time frame: 60 minutes after supplementation
Documents are hosted by the registry — open the source record to download them.
Plan to share: No — Individual participant-level data will not be publicly shared. Aggregated data supporting the findings of this study may be available from the corresponding author upon reasonable request.
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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Ankara University