An interventional study of Physical training program in Myocardial Infarction, sponsored by National Medical Research Center for Therapy and Preventive Medicine. Active, not recruiting. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-03-12.
Sponsored by National Medical Research Center for Therapy and Preventive Medicine · Not applicable, Interventional, and Prevention
Endovascular intervention is one of the most effective treatment for acute coronary syndrome. Therefore, studying the impact of various medical rehabilitation programs on the course of coronary heart disease, patient quality of life, restenosis, and prognosis is of scientific and practical interest. Medical rehabilitation is a crucial stage in patient care after myocardial revascularization. Regular moderate-intensity physical activity helps improve endothelial function and has anti-inflammatory and antithrombogenic effects. Improving a patient's prognosis after myocardial infarction depends on the duration and intensity of cardiac rehabilitation programs, as well as the patient's motivation. Therefore, this issue requires further study, particularly in patients who have undergone endovascular interventions on coronary arteries.
The study was an interventional (clinical) trial, randomized in parallel groups. A total of 1,046 patients were included.
A total of 1,046 patients of both sexes were randomized into two groups. Group 1 (control) patients received standard therapy required for patients undergoing coronary artery stenting during the acute phase of myocardial infarction. They continued their usual physical activity and attended a school for patients with myocardial infarction. Group 2 patients received standard therapy required for patients undergoing coronary artery stenting during the acute phase of myocardial infarction, attended a school for patients with myocardial infarction, and participated in a physical training program. The training program lasted over four months. Postoperatively, patients underwent blood tests, echocardiography, ECG, and bicycle ergometry. The next visit was performed after an average of eight years (with a maximum follow-up period of 11 years). Cardiovascular events were assessed at this stage. Patients who were unable to attend the clinic were interviewed by telephone.
2,744 studies on the registry are indexed under Myocardial Infarction; 418 are open to participants now.
This study's enrollment of 1,046 is above the median of 148 across 1,595 interventional studies indexed under Myocardial Infarction.
Browse Myocardial Infarction studies →National Medical Research Center for Therapy and Preventive Medicine is the lead sponsor of 28 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Integrated Rehabilitation consisting of exercise training and school for patients
Other: Physical training program
Standard follow-up and attending school for patients at the participating heart center
Integrated Rehabilitation consisting of exercise training for at least 1.5 months
Combined
Cardiovascular mortality, non-fatal acute myocardial infarction, non-fatal stroke, need for revascularization
Time frame: 20 years
All-cause mortality
Time frame: 20 years
Composite endpoint of major adverse cardiovascular events (MACE)
Composite endpoint of major adverse cardiovascular events (MACE), defined as the first occurrence of any of the following: recurrent myocardial infarction, ischemic or hemorrhagic stroke, repeat coronary revascularization (PCI or CABG), cardiovascular death.
Time frame: 20 years
cardiovascular mortality
Time frame: 20 years
myocardial infarction
Time frame: 20 years
stroke
Time frame: 20 years
need for revascularization
Time frame: 20 years
hospitalization due to cardiovascular complications
Time frame: 20 years
No study locations are listed for this record.
This study is active, not recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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National Medical Research Center for Therapy and Preventive Medicine