CClinicalTrials.gg
Not yet recruitingNCT07458841Updated Mar 9, 2026

Nurse-Led Discharge Program and Primary Care Outcomes: A Proof-of-concept Cluster Randomized Controlled Trial

An interventional study of Primary healthcare discharge education and specially-designed health education leaflet in Primary Healthcare, sponsored by The University of Hong Kong. Not yet recruiting at 1 site in Hong Kong. Per ClinicalTrials.gov, last updated 2026-03-09.

Sponsored by The University of Hong Kong · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Sex
All
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Study summary

The goal of this cluster randomized controlled trial is to evaluate whether a nurse-led primary health care (PHC) discharge intervention can improve patient activation and primary health care-related outcomes among hospitalized adult patients after discharge.

Read the detailed description

Chronic diseases account for approximately 74% of global deaths and remain the leading cause of morbidity and mortality worldwide and in Hong Kong, particularly ischemic heart disease, cerebrovascular disease, and diabetes-related complications. The growing burden of ageing populations and non-communicable diseases highlights the need to shift healthcare systems from secondary and tertiary care toward prevention-oriented primary health care (PHC).

PHC serves as the first point of contact in a continuous healthcare process and is essential to a sustainable healthcare system. In response, Hong Kong is implementing a PHC reform through the establishment of District Health Centres to enhance population health and reduce pressure on public hospitals. Nurses, as the largest healthcare workforce, play a critical role in PHC delivery; however, nursing training in Hong Kong remains predominantly hospital-focused. Strengthening hospital nurses' roles in PHC-oriented discharge education may improve care continuity, patient self-management, and long-term health outcomes while reducing hospital readmissions and healthcare costs.

The aims of study are as follows:

  1. To determine the main effect of the Intervention vs. Control group on Patient Activation Measure at 3-month follow-up after discharge (Primary)
  2. To assess the effects on secondary outcomes at 3-month and 6-month follow-ups
  3. To identify mediators between intervention and outcomes to inform the potential mechanisms
  4. To qualitatively explore subjects' perceptions of managing their own health conditions after leaving the hospital and their experience of following the primary healthcare discharge intervention suggested by nurses.
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Conditions studied

  • Primary Healthcare

Keywords

  • nurse-led discharge intervention
  • primary healthcare
  • cluster randomized controlled trail
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In context

Lead sponsor

The University of Hong Kong is the lead sponsor of 1,262 studies on the registry; 340 are open to participants now.

Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Hong Kong residents aged ≥18 years
  • Able to read and communicate in Chinese (Cantonese or Mandarin)
  • Being hospitalized for more than 24 hours
  • Stable medical condition upon hospital discharge

Exclusion criteria

Exclusion Criteria:

  • Having a history of psychiatric/psychological disease or currently on regular psychotropic medications
  • Currently participating in other primary healthcare programmes
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Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
120 participants (estimated)

Study arms

  • Experimental
    Intervention group

    1. primary healthcare discharge education 2. specially-designed health education leaflet 3. patient discharge package

    Behavioral: Primary healthcare discharge education · Behavioral: specially-designed health education leaflet · Behavioral: Patient discharge package

  • Active comparator
    Control Group

    usual hospital discharge practice

    Behavioral: usual hospital discharge practice

Interventions

  • BehavioralPrimary healthcare discharge education

    The primary healthcare discharge education begins by identifying priorities to address related to patients' life situations (using the Instrument for Patient Capacity Assessment) and determining the patient's current level of activation (using the Patient Activation Measure). A discharge education guide developed by the research team helps to individualize the teaching according to the patient's priorities and activation level.

  • Behavioralspecially-designed health education leaflet

    1. Introduction of the District Health Centres/Expresses; 2. Life Course Preventive Care Plan pamphlet; 3. Provide disease-specific discharge/rehabilitation advice and relevant health education materials with an emphasis on prevention and self-care management; 4. The hospital nurses will help discharge patients download and install the "HA Go" mobile app.

  • BehavioralPatient discharge package

    Subjects in the intervention group will receive the following items with instructions for use upon hospital discharge: 1. Blood pressure monitor 2. Blood glucose test strip 3. Soft ruler to measure weight circumference 4. Resistance bands for simple exercise

  • Behavioralusual hospital discharge practice

    The control group will receive the usual hospital discharge practice upon discharge.

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What researchers measure

Primary outcomes

  1. The primary outcome is the change in the Patient Activation Measure (PAM) between baseline and 3-month follow-up.

    The PAM is a 13-item self-report questionnaire to measure patient activation level \[18\]. Patients can go through four levels of activation: (1) disengaged and overwhelmed, (2) becoming aware but still struggling, (3) taking action, and (4) maintaining behaviors and pushing further \[18\].PAM raw score can be calculated by adding all of the responses to the 13 questions \[18\]. This score is then converted into an activation score ranging from 0 = no activation to 100 = high activation using a scoresheet provided by Insignia Health.

    Time frame: From baseline to 3-month follow up.

07

Study locations

1 site
  • 18/F, Metro South Tower 1, 39 Wong Chuk Hang Road, Wong Chuk Hang, Hong Kong
    Hong Kong, Hong Kong 000000, Hong Kong
    • Siu Long Chau, PhD · Contact · cslmatt@hku.hk · +852 6700 9987
    • Siu Long Chau, PhD · Principal investigator
08

References and documents

Publications

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  • Ingram PB 4th, Clarke E, Lichtenberg JW. Confirmatory Factor Analysis of the Perceived Stress Scale-4 in a Community Sample. Stress Health. 2016 Apr;32(2):173-6. doi: 10.1002/smi.2592. Epub 2014 Jul 4. PubMed 24995556 ↗
  • Adzrago D, Walker TJ, Williams F. Reliability and validity of the Patient Health Questionnaire-4 scale and its subscales of depression and anxiety among US adults based on nativity. BMC Psychiatry. 2024 Mar 18;24(1):213. doi: 10.1186/s12888-024-05665-8. PubMed 38500115 ↗
  • Shmueli A. The Visual Analog rating Scale of health-related quality of life: an examination of end-digit preferences. Health Qual Life Outcomes. 2005 Nov 14;3:71. doi: 10.1186/1477-7525-3-71. PubMed 16285884 ↗
  • Weiss ME, Piacentine LB. Psychometric properties of the Readiness for Hospital Discharge Scale. J Nurs Meas. 2006 Winter;14(3):163-80. doi: 10.1891/jnm-v14i3a002. PubMed 17278337 ↗
  • Benson T, Potts HWW, Bark P, Bowman C. Development and initial testing of a Health Confidence Score (HCS). BMJ Open Qual. 2019 Jun 7;8(2):e000411. doi: 10.1136/bmjoq-2018-000411. eCollection 2019. PubMed 31259277 ↗
  • Chalmers KI, Luker KA, Bramadat IJ. Students' knowledge of and attitudes towards primary health care. Nurse Educ Today. 1998 Jul;18(5):399-405. doi: 10.1016/0021-8634(92)80010-p. PubMed 9847729 ↗
  • Schmaderer M, Pozehl B, Hertzog M, Zimmerman L. Psychometric Properties of the Patient Activation Measure in Multimorbid Hospitalized Patients. J Nurs Meas. 2015;23(3):128-41. doi: 10.1891/1061-3749.23.3.E128. PubMed 26673761 ↗
  • French SD, Green SE, O'Connor DA, McKenzie JE, Francis JJ, Michie S, Buchbinder R, Schattner P, Spike N, Grimshaw JM. Developing theory-informed behaviour change interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework. Implement Sci. 2012 Apr 24;7:38. doi: 10.1186/1748-5908-7-38. PubMed 22531013 ↗
  • Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011 Apr 23;6:42. doi: 10.1186/1748-5908-6-42. PubMed 21513547 ↗
  • Atkins L, Francis J, Islam R, O'Connor D, Patey A, Ivers N, Foy R, Duncan EM, Colquhoun H, Grimshaw JM, Lawton R, Michie S. A guide to using the Theoretical Domains Framework of behaviour change to investigate implementation problems. Implement Sci. 2017 Jun 21;12(1):77. doi: 10.1186/s13012-017-0605-9. PubMed 28637486 ↗
  • Hibbard JH, Stockard J, Mahoney ER, Tusler M. Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers. Health Serv Res. 2004 Aug;39(4 Pt 1):1005-26. doi: 10.1111/j.1475-6773.2004.00269.x. PubMed 15230939 ↗
  • Chau SL, Luk TT, Wong BYC, Wu YS, Cheung YTD, Ho SY, Kim JH, Lo HHM, Lam TH, Wang MP. A Brief Intervention With Instant Messaging or Regular Text Messaging Support in Reducing Alcohol Use: A Randomized Clinical Trial. JAMA Intern Med. 2024 Jun 1;184(6):641-649. doi: 10.1001/jamainternmed.2024.0343. PubMed 38587827 ↗
  • Chan SS, Wong DC, Cheung YT, Leung DY, Lau L, Lai V, Lam TH. A block randomized controlled trial of a brief smoking cessation counselling and advice through short message service on participants who joined the Quit to Win Contest in Hong Kong. Health Educ Res. 2015 Aug;30(4):609-21. doi: 10.1093/her/cyv023. Epub 2015 Jun 25. PubMed 26116584 ↗
  • International Council of Nurses. Position statements on primary health care. Geneva, Switzerland: International Council of Nurses; 2024. Retrieved on 05 Oct 2024 from: https://www.icn.ch/what-we-do/position-statements
  • Riegel B, Sullivan-Marx E, Fairman J. Meeting global needs in primary care with nurse practitioners. Lancet. 2012 Aug 4;380(9840):449-50. doi: 10.1016/S0140-6736(12)60241-4. No abstract available. PubMed 22863040 ↗
  • Boniol M, Kunjumen T, Nair TS, Siyam A, Campbell J, Diallo K. The global health workforce stock and distribution in 2020 and 2030: a threat to equity and 'universal' health coverage? BMJ Glob Health. 2022 Jun;7(6):e009316. doi: 10.1136/bmjgh-2022-009316. PubMed 35760437 ↗
  • Adhikari R, Smith P. Global nursing workforce challenges: Time for a paradigm shift. Nurse Educ Pract. 2023 May;69:103627. doi: 10.1016/j.nepr.2023.103627. Epub 2023 Apr 1. No abstract available. PubMed 37018998 ↗
  • Health Bureau. Legislative Council Paper No. CB(4)88/2023(03). Hong Kong SAR; 2024. Retrieved on 05 Oct 2024 from: https://www.legco.gov.hk/yr2023/english/panels/hs/papers/hs20230210cb4-88-3-e.pdf
  • Allen LN, Pettigrew LM, Exley J, Nugent R, Balabanova D, Villar-Uribe M, Baatiema L, Shubber Z, Mugambi J, Kidd M, Zewdie A, Padula I, Abimbola S. The role of Primary Health Care, primary care and hospitals in advancing Universal Health Coverage. BMJ Glob Health. 2023 Dec 7;8(12):e014442. doi: 10.1136/bmjgh-2023-014442. No abstract available. PubMed 38084496 ↗
  • Rifkin SB. Paradigms, policies and people: the future of primary health care. BMJ Glob Health. 2020 Feb 23;5(2):e002254. doi: 10.1136/bmjgh-2019-002254. eCollection 2020. No abstract available. PubMed 32133199 ↗
  • Department of Health. Report of population health survey 2020/22, Hong Kong SAR; 2022. Retrieved on 06 Dec 2023 from: https://www.chp.gov.hk/en/static/51256.html
  • Wong ELY, Xu RH, Cheung AWL. Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study. PLoS One. 2019 Nov 20;14(11):e0224970. doi: 10.1371/journal.pone.0224970. eCollection 2019. PubMed 31747393 ↗
  • Hajat C, Stein E. The global burden of multiple chronic conditions: A narrative review. Prev Med Rep. 2018 Oct 19;12:284-293. doi: 10.1016/j.pmedr.2018.10.008. eCollection 2018 Dec. PubMed 30406006 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 9, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07458841
Lead sponsor
The University of Hong Kong
Collaborators
Queen Mary Hospital, Hong Kong
Responsible party
Sponsor
First posted
Mar 9, 2026
Start date
Mar 1, 2026 (estimated)
Primary completion
Feb 1, 2027 (estimated)
Completion
Jun 1, 2027 (estimated)
Last update
Mar 9, 2026

Study contacts

Siu Long Chau, PhD
Contact
cslmatt@hku.hk
+852 6700 9987
Siu Long Chau, PhD
principal investigator · HKU

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is not yet recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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