An observational study in Genetic Predisposition, sponsored by St. Jude Children's Research Hospital. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-18.
Sponsored by St. Jude Children's Research Hospital · Observational
This observational study evaluates whether adolescents and young adults (AYAs) with a cancer predisposition syndrome (CPS) establish and maintain adult health care and continue CPS-specific cancer surveillance after graduating from pediatric care at St. Jude Children's Research Hospital (SJCRH). Participants will complete a Readiness Assessment and periodic surveys over 8 years post-graduation.
Primary Objectives
Exploratory Objectives:
The OnTRAC study investigates the outcomes of AYAs with CPS following their transition from pediatric to adult health care. The study aims to assess whether participants establish care with adult providers and adhere to recommended cancer surveillance protocols. Participants will complete a Readiness Assessment one month post-graduation and electronic Transition Outcomes Surveys at 1, 3, 5, and 8 years. These surveys will evaluate health care engagement, cancer screening adherence, barriers and facilitators to care, and psychosocial experiences. The study will also explore clinical and demographic correlates of successful transition and surveillance adherence.
235 studies on the registry are indexed under Genetic Predisposition to Disease; 94 are open to participants now.
This study's planned enrollment of 56 is below the median of 400 across 154 observational studies indexed under Genetic Predisposition to Disease.
Browse Genetic Predisposition to Disease studies →St. Jude Children's Research Hospital is the lead sponsor of 434 studies on the registry; 99 are open to participants now.
Of its 60 completed or terminated interventional studies of FDA-regulated products, 35 (58%) have results posted.
Counted across the registry records on this site, refreshed daily.
All participants who meet eligibility criteria and consent to enrollment on the study
Exclusion Criteria:
AYAs with CPS who have graduated from SJCRH and are followed longitudinally through surveys and assessments to evaluate health care transition outcomes.
Behavioral: Readiness Assessment · Behavioral: Transition Outcomes Survey A · Behavioral: Transition Outcomes Survey B
Electronic assessment administered 1 month post-graduation to evaluate transition preparedness.
Administered at 1 and 3 years post-graduation to assess health care engagement and psychosocial outcomes.
Administered at 5 and 8 years post-graduation to assess long-term outcomes and cancer surveillance adherence.
Establishment of Adult Health Care
Proportion of Young Adults with Cancer Predisposition Syndromes Who Have an Identified Adult Medical Provider Managing Cancer Surveillance One Year Post-Pediatric Care Transition
Time frame: Evaluated 1 year after consent from the study.
Maintenance of Adult Health Care
Proportion of Young Adults with Cancer Predisposition Syndromes Who Maintain an Identified Adult Medical Provider for Cancer Surveillance Three Years Post-Pediatric Care Transition
Time frame: Evaluated 3 years after consent from the study.
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Genetic Predisposition to Disease→
St. Jude Children's Research Hospital