An interventional study of Resistance Training Group (RT) and Control in Older Men, Quality of Life and Fatty Liver, sponsored by Gümüşhane Universıty. Completed at 1 site in Turkey (Türkiye). Open to male participants aged 60 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by Gümüşhane Universıty · Not applicable, Interventional, and Other
This randomized controlled trial investigated the effects of a four-week moderate-intensity resistance training program on diaphragm thickness, hepatic fat density, and health-related quality of life in healthy community-dwelling older men aged 60-75 years. Thirty participants were randomly assigned to a resistance training group or control group. Diaphragm thickness and hepatic attenuation were assessed using non-contrast computed tomography, and quality of life was evaluated using the SF-12 questionnaire. The primary outcome was change in diaphragm thickness. Secondary exploratory outcomes included hepatic fat density and SF-12 physical and mental health scores.
Aging is associated with progressive decline in respiratory muscle morphology, metabolic health, and perceived quality of life. While resistance training is well established for peripheral muscle adaptation, its short-term effects on diaphragm morphology and hepatic tissue density remain insufficiently investigated.
This randomized controlled pre-test-post-test trial enrolled 30 healthy men aged 60-75 years. Participants were randomly allocated (1:1) to:
Resistance Training Group (RT) Control Group (CON) The RT group completed a supervised moderate-intensity resistance training program three times per week for four weeks (30-40 minutes/session, RPE 12-15). The control group maintained usual daily activities.
Primary Outcome:
Change in diaphragm thickness (mm) assessed by non-contrast CT
Secondary Outcomes (Exploratory):
Hepatic attenuation (Hounsfield Units) via CT SF-12 Physical Health Score SF-12 Mental Health Score The study was approved by the Hitit University Scientific Research Ethics Committee (2025/0464) and conducted according to the Declaration of Helsinki.
1,451 studies on the registry are indexed under Fatty Liver; 292 are open to participants now.
This study's enrollment of 30 is below the median of 60 across 1,003 interventional studies indexed under Fatty Liver.
Browse Fatty Liver studies →Gümüşhane Universıty is the lead sponsor of 34 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants performed supervised resistance training three times per week for four weeks. Each session lasted 30-40 minutes and included: Lower body exercises (sit-to-stand, step-ups, glute bridge) Upper body exercises (wall push-ups, resistance band row, biceps curl) Core exercises Breathing exercises (diaphragmatic breathing, pursed-lip breathing) Warm-up protocol (10 minutes dynamic mobility) Intensity: Borg RPE 12-15 Rest interval: 60 seconds between sets
Behavioral: Resistance Training Group (RT) · Other: Control
Participants maintained their usual daily routines without structured exercise intervention.
Structured Moderate-Intensity Resistance Training
Participants maintained their usual daily routines without structured exercise intervention.
Diaphragm Thickness
Diaphragm thickness measured in millimeters using non-contrast computed tomography at full inspiration.
Time frame: 4 weeks
Hepatic Fat Density
Measurement: CT attenuation (Hounsfield Units) Single ROI in segment VIII
Time frame: 4 weeks
SF-12 Physical Health Score
Instrument: Short Form-12 Health Survey The physical and mental health scores of the SF-12 subdimensions range from 0 to 100, with higher scores representing better health.
Time frame: 4 weeks
SF-12 Mental Health Score
Instrument: Short Form-12 Health Survey The physical and mental health scores of the SF-12 subdimensions range from 0 to 100, with higher scores representing better health.
Time frame: 4 weeks
Six-minute walk test (6MWT)
Functional exercise capacity was assessed using the 6-Minute Walk Test (6MWT) according to a standardised protocol based on established 6MWT recommendations. The test was performed on a flat, straight 30-m indoor corridor, with the course clearly marked at both ends. Participants were instructed to walk back and forth along the corridor for 6 min at a self-selected walking pace, with the objective of covering the greatest possible distance within the allotted time.
Time frame: 4 WEEK
Plan to share: No — Individual participant data will not be shared due to the absence of prior consent for data sharing and the potential risk of re-identification in a small, single-center sample. Only aggregate results will be disseminated.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Gümüşhane Universıty