An observational study in Preecalmpsia, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to female participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-03-11.
Sponsored by Cairo University · Observational
Preeclampsia with severe features remains a leading contributor to maternal morbidity and mortality, particularly in low- and middle-income countries. It is defined by hypertension and involvement of multiple organ systems, including renal, hepatic, hematologic, and neurologic pathways. The interplay of endothelial dysfunction, capillary leakage, and disrupted fluid balance in these patients increases their susceptibility to perioperative pulmonary complications. Although respiratory complications in preeclampsia are clinically significant, the true incidence of postoperative diaphragmatic dysfunction in women with severe disease is not well established. Existing literature largely emphasizes general respiratory failure, pulmonary edema, or the need for mechanical ventilation, rather than specifically evaluating diaphragmatic performance with objective methods such as ultrasound. The current study sought to determine the incidence and identify risk factors for postoperative diaphragmatic dysfunction in women with severe preeclampsia following cesarean delivery.
882 studies on the registry are indexed under Pre-Eclampsia; 237 are open to participants now.
This study's planned enrollment of 52 is below the median of 163 across 380 observational studies indexed under Pre-Eclampsia.
Browse Pre-Eclampsia studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
This prospective observational study will enroll pregnant women aged 20-40 years present to the emergency department with a diagnosis of preeclampsia with severe features and are scheduled for cesarean delivery
Exclusion Criteria:
Age \< 20 years.
diaphragmatic excursion evaluation
The incidence of postoperative diaphragmatic dysfunction
diaphragmatic dysfunction is defined as a mean diaphragmatic excursion of less than 10 mm
Time frame: Diaphragmatic excursion is measured before and 24 hours after surgery.
Percentage of change in DE
Percentage of change in diaphragmatic excursion from baseline to 24 hours after surgery
Time frame: 24 hours after surgery
Risk factors associated with postoperative diaphragmatic dysfunction
Regression analysis to detect risk factors
Time frame: 24 hours after surgery
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Cairo University