An interventional study of Leptin Balance Formula in Hunger and Weight Change, sponsored by Efforia, Inc. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-02.
Sponsored by Efforia, Inc · Not applicable, Interventional, and Health services research
This study evaluates changes in hunger perception and body composition-related measures following daily use of a commercially available dietary supplement formulated to support leptin-related metabolic signaling. Adult participants will self-administer the supplement for 12 weeks and complete periodic self-reported assessments related to appetite, hunger, and weight-related outcomes. Participants serve as their own control, with comparisons made between baseline and follow-up measurements. The study is designed to generate preliminary, real-world evidence regarding supplement use in a general wellness context.
Leptin is a hormone involved in appetite regulation and satiety signaling. Dysregulation of leptin signaling has been associated with altered hunger perception and weight management challenges. While diet and physical activity are commonly emphasized in weight optimization strategies, hormonal contributors such as leptin are less frequently evaluated in real-world consumer settings.
This single-arm, observational study is designed to explore changes in hunger perception and weight-related outcomes associated with daily use of the Leptin Balance Formula, a commercially available dietary supplement containing African mango seed extract, chromium picolinate, Ceylon cinnamon, and alpha lipoic acid. Participants will use the product for 12 weeks and complete electronic surveys and self-reported measurements at baseline and designated follow-up time points.
The study is conducted under Efforia's Minimal Risk Umbrella Protocol and is intended as a signal-detection study to inform future, more controlled research designs. The study does not diagnose, treat, or prevent disease and is limited to general health and wellness outcomes.
Study Design
Study Type: Observational
Observational Model: Single Group Assignment
Time Perspective: Prospective
Number of Arms: 1
Masking: None (Open Label)
Primary Purpose: Other (Wellness / Signal Detection)
More information can be found at the study recruitment landing page: https://app.efforia.com/leptin-balance-formula-weight-optimization/
231 studies on the registry are indexed under Body Weight Changes; 30 are open to participants now.
This study's planned enrollment of 100 is above the median of 80 across 179 interventional studies indexed under Body Weight Changes.
Browse Body Weight Changes studies →Efforia, Inc is the lead sponsor of 25 studies on the registry; 20 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Single Arm longitudinal where participants act as their own control
Dietary Supplement: Leptin Balance Formula
Participants will self-administer the Leptin Balance Formula daily for 12 weeks according to product labeling. The supplement is commercially available and includes African mango seed extract, chromium picolinate, Ceylon cinnamon, and alpha lipoic acid.
Change in Hunger Perception
Change from baseline in self-reported hunger perception as measured by a standardized hunger perception questionnaire.
Time frame: Baseline and Week 12
Change in Body Weight
Self-reported body weight change from baseline.
Time frame: Baseline and Week 12
After-Meal Hunger and Fatigue Perception
Self-reported hunger and fatigue levels following meals using a structured questionnaire.
Time frame: Baseline, Week 4, Week 8, and Week 12
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