An observational study in Burnout, Secondary Traumatic Stress and Occupational Stress, sponsored by Elazıg Fethi Sekin Sehir Hastanesi. Completed at 1 site in Turkey (Türkiye). Per ClinicalTrials.gov, last updated 2026-04-23.
Sponsored by Elazıg Fethi Sekin Sehir Hastanesi · Observational
Healthcare professionals working in intensive care units (ICUs) are frequently exposed to high levels of psychological stress due to critically ill patients, frequent encounters with death, complex clinical decision-making, and prolonged working hours. This environment increases the risk of burnout and secondary traumatic stress, which may not only affect mental well-being but also have measurable physiological consequences.
Emerging evidence suggests that chronic psychological stress and burnout may influence immune function through activation of proinflammatory pathways. Elevated levels of inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and neutrophil-to-lymphocyte ratio (NLR) have been associated with stress-related conditions. However, data examining the relationship between burnout, secondary traumatic stress, and inflammatory biomarkers in intensive care healthcare workers remain limited.
This cross-sectional observational study aims to investigate the association between burnout and secondary traumatic stress levels, assessed using validated psychometric instruments (Maslach Burnout Inventory and Professional Quality of Life Scale), and inflammatory biomarkers (CRP, IL-6, TNF-α, and NLR) in ICU healthcare workers. Blood samples will be obtained in conjunction with routine annual health screening, and additional serum samples will be collected for biomarker analysis. The study seeks to clarify the psychoneuroimmunological mechanisms underlying occupational stress in critical care settings.
442 studies on the registry are indexed under Burnout, Psychological; 106 are open to participants now.
This study's enrollment of 140 is below the median of 206 across 113 observational studies indexed under Burnout, Psychological.
Browse Burnout, Psychological studies →Elazıg Fethi Sekin Sehir Hastanesi is the lead sponsor of 29 studies on the registry; 7 are open to participants now.
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The study population consists of healthcare professionals working in intensive care units (anesthesia, internal medicine, and chest diseases ICUs) at Elazığ Fethi Sekin City Hospital. Participants include physicians, nurses, anesthesia technicians, and other healthcare staff who are actively involved in the care of critically ill patients. All participants are adults undergoing routine annual occupational health screening and voluntarily agree to participate in the study.
Active employment in an intensive care unit (anesthesia, internal medicine, or chest diseases ICU)
Participation in routine annual occupational health screening
Willingness to provide additional blood sample for research purposes
Voluntary participation with written informed consent
Exclusion Criteria:
Use of systemic steroids, immunosuppressive agents, or chemotherapy within the last 4 weeks
Known autoimmune or rheumatologic disease
Hematologic malignancy or severe hematologic disorder
Pregnancy
Refusal to provide additional blood sample
Incomplete questionnaire data
Healthcare professionals aged 18 years and older working in intensive care units (anesthesia, internal medicine, and chest diseases ICUs) who voluntarily participate in the study. Participants will complete validated psychometric scales assessing burnout and secondary traumatic stress, and blood samples will be collected for inflammatory biomarker analysis.
Other: Psychometric Assessment and Blood Sampling
Administration of validated burnout and secondary traumatic stress questionnaires and collection of blood samples for inflammatory biomarker analysis. No therapeutic or clinical intervention is performed.
Association Between Burnout Levels and Inflammatory Biomarkers
Evaluation of the relationship between Maslach Burnout Inventory (MBI-HSS) total and subscale scores and inflammatory biomarker levels (CRP, IL-6, TNF-α, and NLR) using correlation and multivariable linear regression analysis.
Time frame: At the time of assessment (single time point)
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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Elazıg Fethi Sekin Sehir Hastanesi