An interventional study of Furosemide plus albumin and Furosemide (Diuretic) in Urine Output Decreased, sponsored by Jose J Zaragoza, MD MSc. Recruiting at 1 site in Mexico. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-06-16.
Sponsored by Jose J Zaragoza, MD MSc · Not applicable, Interventional, and Treatment
This study aims to compare the effectiveness of furosemide alone versus the combination of furosemide plus albumin in critically ill adult patients with fluid overload. The trial evaluates whether co-administration of albumin enhances diuretic response compared with standard furosemide therapy. The primary outcomes include urine output at 2 hours, changes in renal perfusion markers, and biochemical parameters. Secondary outcomes include changes in mean arterial pressure, electrolyte balance, and renal resistance index. The study seeks to determine whether adding albumin provides a clinically meaningful improvement in diuresis and renal function compared with furosemide monotherapy.
This randomized clinical study evaluates two diuretic strategies for fluid overload in adult critically ill patients: furosemide monotherapy versus combined therapy with furosemide plus albumin. Albumin may enhance diuretic effectiveness by increasing intravascular oncotic pressure, improving renal perfusion, and facilitating drug delivery to the nephron.
The protocol includes standardized dosing, measurement of urine output at 2 hours, and analysis of serum and urine biochemical parameters. Bedside ultrasound will be used to assess markers of fluid overload, including evaluation of the inferior vena cava and venous congestion patterns. Hemodynamic variables, electrolyte changes, and estimated glomerular filtration rate will also be monitored.
The study aims to determine whether the co-administration of albumin provides a clinically meaningful improvement in diuretic response and renal function compared with furosemide monotherapy in critically ill patients with fluid overload.
566 studies on the registry are indexed under Edema; 95 are open to participants now.
This study's planned enrollment of 56 is close to the median of 52 across 401 interventional studies indexed under Edema.
Browse Edema studies →This is the only study on the registry with Jose J Zaragoza, MD MSc as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Participants receive furosemide 1 mg/kg IV as a single dose infused over 30 minutes, plus placebo (normal saline).
Drug: Furosemide (Diuretic)
Participants receive furosemide 1 mg/kg IV together with 50 g of 25% albumin, infused over 30 minutes.
Drug: Furosemide plus albumin
Drug pages: Furosemide · Albumins
Furosemide 1 mg/kg IV administered together with 50 grams of 25% albumin (one vial), infused over 30 minutes.
Furosemide 1 mg/kg IV as a single dose, infused over 30 minutes, plus placebo (normal saline).
Urine output (mL) at 2 hours after administration of the assigned treatment
Total urine output measured in milliliters within the first 2 hours after administration of the assigned treatment (furosemide alone or furosemide plus albumin), using a urinary catheter and standard collection methods.
Time frame: 2 hours after administration of the study treatment.
Change in inferior vena cava (IVC) diameter and venous congestion patterns at 2 hours
Change in inferior vena cava (IVC) diameter (mm) and venous congestion patterns assessed by bedside ultrasound from baseline to 2 hours after treatment administration.
Time frame: baseline to 2 hours
Change in Serum Potassium Concentration
Change in serum potassium concentration from baseline to 24 hours after administration of the assigned treatment.
Time frame: 24 hours
Change in Serum Creatinine
Change in serum creatinine from baseline to 24 hours after administration of the assigned treatment.
Time frame: Baseline to 24 hours.
Change in Serum Sodium Concentration
Change in serum sodium concentration from baseline to 24 hours after administration of the assigned treatment.
Time frame: 24 hours
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drugs tested here: Furosemide · Albumins