An observational study in Lower Respiratory Tract Infections, Community Acquired Pneumonia (CAP) and Acute Bronchitis, sponsored by Hôpital Raymond Poincaré. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-18.
Sponsored by Hôpital Raymond Poincaré · Observational
Primary aim:
To describe participant characteristics at the time of the index lower respiratory tract infection (LRTI) episode in adults managed in primary care in France, using anonymized electronic health records from routine clinical practice between January 2015 and December 2024.
Secondary aims:
To describe and quantify patterns of antibiotic prescribing (rate, type, and duration of treatment) and short-term outcomes, including LRTI-related reconsultations and severe complications within 30 days after the index consultation.
The overall objective is to better characterize real-world management and outcomes of lower respiratory tract infections in primary care and to identify potential areas for improving quality of care and optimizing antibiotic stewardship.
Lower respiratory tract infections are a frequent reason for consultation and antibiotic prescribing in primary care. However, nationally representative data describing real-world management in routine practice remain limited in France.
This nationwide retrospective observational study uses anonymized electronic health records from the THIN® France database, a large primary care data warehouse collecting routinely recorded clinical data from general practitioners. The study includes adults aged 18 years and older with a recorded episode of community-acquired lower respiratory tract infection between January 2015 and December 2024.
Each participant contributes a single index episode and is followed for 30 days to assess short-term outcomes. The study period allows the evaluation of management practices over a 10-year timeframe in routine ambulatory care.
The main objective is to describe patients characteristics and real-world management of lower respiratory tract infections in primary care, with a focus on patterns of care, treatment strategies, and short-term outcomes. This study is based exclusively on previously collected anonymized data and does not involve any intervention or change in patient care.
By providing a large-scale overview of routine practice, the study aims to improve understanding of current management approaches and identify potential areas for optimizing antibiotic use in primary care.
324 studies on the registry are indexed under Community-Acquired Pneumonia; 77 are open to participants now.
This study's enrollment of 230,066 is above the median of 650 across 111 observational studies indexed under Community-Acquired Pneumonia.
Browse Community-Acquired Pneumonia studies →Hôpital Raymond Poincaré is the lead sponsor of 4 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients (≥18 years) with a recorded episode of community-acquired lower respiratory tract infection (LRTI) in French primary care between January 1, 2015 and December 31, 2024, identified from anonymized electronic health records in the THIN France database. Patients were required to have at least 12 months of prior medical history before the index episode.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Adults with a recorded community-acquired lower respiratory tract infection (LRTI) in primary care in France between January 2015 and December 2024 whose index episode was associated with an antibiotic prescription during routine care. No intervention was assigned by the study.
Adults with a recorded community-acquired lower respiratory tract infection (LRTI) in primary care in France between January 2015 and December 2024 whose index episode was not associated with an antibiotic prescription during routine care. No intervention was assigned by the study.
Participant Characteristics at Index LRTI Episode
Descriptive summary of participant characteristics at the index lower respiratory tract infection episode, including age, sex, body mass index, smoking status, alcohol use, comorbidities, and vaccination status, overall and by antibiotic exposure group.
Time frame: Index consultation
Antibiotic Prescribing Rate
Proportion of participants with an antibiotic prescription at the index episode, stratified on LRTI type
Time frame: Index consultation
Type of Antibiotics Prescribed for Antibiotic-treated LRTIs
Distribution of antibiotic classes prescribed at the index episode.
Time frame: Index consultation
Duration of Antibiotic Treatment for Antiobiotic-treated LRTIs
Duration of antibiotic treatment prescribed for the index episode.
Time frame: Index consultation
30-Day LRTI-Related Reconsultation Rate
Proportion of participants with a follow-up consultation related to LRTI within 30 days.
Time frame: 30 days
30-Day Severe Complication Rate After LRTI
Occurrence of Sepsis/septic shock, Pleural effusion, Lung abscess, Acute respiratory distress syndrome (ARDS) within 30 days after the index episode.
Time frame: 30 days
No study locations are listed for this record.
Plan to share: No — Individual participant data come from an anonymized database with legal and contractual restrictions.
No publications or documents are linked to this record.
Ran from Jan 2015 to primary completion in Dec 2024, 119 months.
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This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Community-Acquired Pneumonia →
Hôpital Raymond Poincaré