An interventional study of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in Accelerate Tooth Movement, sponsored by Sana'a University. Completed at 1 site in Yemen. Open to participants aged 17 Years to 29 Years. Per ClinicalTrials.gov, last updated 2026-02-13.
Sponsored by Sana'a University · Not applicable, Interventional, and Treatment
This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.
Sana'a University is the lead sponsor of 27 studies on the registry; 15 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
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Platelets
Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Split-mouth group in which one side received platelet-rich plasma (PRP) injection and the contralateral side served as a control without injection during orthodontic canine retraction.
Biological: Platelet-Rich Plasma (PRP)
Split-mouth group in which one side received platelet-rich fibrin (PRF) injection and the contralateral side served as a control without injection during orthodontic canine retraction.
Biological: Platelet-Rich Fibrin (PRF)
Autologous platelet-rich plasma prepared from the patient's own blood and injected locally at the experimental side to accelerate orthodontic canine retraction.
Autologous platelet-rich fibrin prepared from the patient's own blood and injected locally to accelerate orthodontic canine retraction.
Rate of Orthodontic Canine Retraction
The amount of orthodontic canine movement measured in millimeters.
Time frame: From baseline (initiation of orthodontic canine retraction) until completion of canine retraction, assessed monthly for up to 4 months.
Plan to share: No — Individual participant data will not be shared because this study was conducted as part of a master's degree thesis and the data are subject to institutional and ethical restrictions.
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This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Platelet rich plasma · P-prf
Sana'a University