An interventional study of Dexmedetomidine and Midazolam in Emergence Agitation, sponsored by Muhammad Aamir Latif. Completed at 2 sites in Pakistan. Open to participants aged 16 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-02-06.
Sponsored by Muhammad Aamir Latif · Not applicable, Interventional, and Treatment
Since the frequency of emergence agitation (EA) is relatively high in children while undergoing nasal surgery, and there is not much data available in Pakistan regarding EA in adults undergoing functional endoscopic sinus surgery (FESS). Hence there is a need to conduct this study in the local population to see the effect of dexmedetomidine and midazolam on EA. Therefore, the current study was initiated, aiming to compare the effect of dexmedetomidine and midazolam on EA in patients undergoing FESS.
There is not much local data present on the topic of EA. As the frequency of EA is relatively high, it can lead to any unwanted event, which can lead to other complications in the patients undergoing nasal surgery. Although in some studies dexmedetomidine has been found to significantly reduce the frequency of EA and severity, provide better sedation, and lower the need for postoperative rescue analgesia in patients undergoing FESS, few others have claimed comparable results for midazolam as well. The findings of this study would not only add to the local data but also be helpful in determining a better option in reducing the frequency of this phenomenon in patients undergoing FESS under general anesthesia.
763 studies on the registry are indexed under Emergence Delirium; 241 are open to participants now.
This study's enrollment of 146 is above the median of 120 across 475 interventional studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Muhammad Aamir Latif is the lead sponsor of 56 studies on the registry; 9 are open to participants now.
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Patients were given a dexmedetomidine injection with a loading dose of 1 µg/kg in 10 minutes prior to the procedure.
Drug: Dexmedetomidine
Patients received a midazolam injection with a loading dose of 0.02 mg/kg in 10 min prior the procedure.
Drug: Midazolam
Patients were given dexmedetomidine injection with a loading dose of 1 µg/kg in 10 minute prior to the procedure.
Patients received midazolam with a loading dose of 0.02 mg/kg in 10 min prior to the procedure.
Effectiveness in emergence agitation
The effectiveness of the treatment was assessed through Ricker's sedation and agitation score, with a score of 4 as efficacy 'yes'.
Time frame: 90 minutes
Plan to share: No — Data can be shared on a reasonable request.
No publications or documents are linked to this record.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Muhammad Aamir Latif