An interventional study of Low-Load Resistance Training and High-Load Resistance Training in Activity, Motor, sponsored by University of Miami. Recruiting at 1 site in United States. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-02-02.
Sponsored by University of Miami · Not applicable, Interventional, and Treatment
This study will compare the effects of high-load resistance training to low-load resistance training, on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.
2,426 studies on the registry are indexed under Motor Activity; 1,161 are open to participants now.
This study's planned enrollment of 60 is close to the median of 60 across 2,118 interventional studies indexed under Motor Activity.
Browse Motor Activity studies →University of Miami is the lead sponsor of 820 studies on the registry; 161 are open to participants now.
Of its 111 completed or terminated interventional studies of FDA-regulated products, 93 (84%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants will receive low-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.
Behavioral: Low-Load Resistance Training
Participants will receive high-load resistance training, twice per week for at least 24 sessions for up to 12 weeks.
Behavioral: High-Load Resistance Training
Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using three sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises.
Participants will receive a total of twenty-four 45-minutes in-person training sessions, twice per week using four sets of eight repetitions per set. During training participants will be allowed 2-minute rests between sets. Exercises will include four upper-body exercises and two lower-body exercises.
Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.
Time frame: [Time Frame: Baseline, 12 weeks]
Change in neuromuscular performance as measured by Power Production
This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. Unit of measure is Watts.
Time frame: Baseline, 12 weeks
Change in the Speed of the Ten-Meter Walk Test.
The ten-meter walk test will be used to assess gait velocity. The participants will be asked to walk at usual walking speed and as quickly as possible in a straight line on a 10-m course marked at 0, 2, 8 and 10 m. On verbal command, participants will start on the 0-m mark and stop when the 10-m mark is crossed. The total time to ambulate from the 2-m mark to the 8-m mark (6 m total) will be timed to the hundredth of a second. Two trials will be performed at each speed, and the average will be documented in meters per second. One-minute recoveries will be provided between trials.
Time frame: Baseline, 12 weeks
Change in Time for the Five Times Sit-to-Stand Test.
The five-time sit-to-stand test will be used to assess functional lower body strength. The participant will sit with arms folded across the chest and the back against the chair. On a verbal command, the participant will stand up and sit down five times as quickly as possible. Timing begins at the word go and ends when the buttocks touch the chair after the fifth repetition. One practice and two testing trials will be performed. Time will be measured in seconds.
Time frame: Baseline, 12 weeks
Change in the time required to complete the timed Up-and-Go Test.
Upon verbal cue, the subject stands up, walks around a cone placed three meters from the front edge of the chair and then returns to a seated position as quickly as possible. Time is measured in seconds.
Time frame: Baseline, 12 weeks
Change in Distance of the Seated Medicine Ball Throw.
For the Seated Medicine Ball Throw, subjects will sit in an armless chair with the back against the chair back, while holding the 6-pound medicine ball against the chest. Subjects will then throw the ball at a perceived 45° angle as far as possible. Subjects must complete at least three practice trials; however, subjects will be allowed more trials until comfortable with the testing procedure. Upon starting the official trial, subjects will complete three separate attempts at each varying medicine ball, to nine trials in total. Each of the three trials within a given medicine ball test will be separated by a 1-minute rest. Distance will be measured in centimeters.
Time frame: Baseline, 12 weeks
Plan to share: No
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