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Not yet recruitingNCT07351448Updated Jan 20, 2026

Research on the Extraction of Tongue and Facial Diagnosis Features of Psoriasis Vulgaris in Traditional Chinese Medicine and Its Correlation With Laboratory Indicators

An observational study in Psoriasis (PsO), Traditional Chinese Medicine (TCM) and Diagnosis, sponsored by Shanghai Yueyang Integrated Medicine Hospital. Not yet recruiting at 1 site in China. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-20.

Sponsored by Shanghai Yueyang Integrated Medicine Hospital · Observational

Study type
Observational
Model
Other
Time perspective
Cross-sectional
Enrollment
450
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Psoriasis Vulgaris is a chronic, inflammatory, and immune-activated skin disease. It is the most common type of psoriasis, accounting for approximately 85-90% of all psoriasis patients. Its clinical features include erythema, papules, covered with varying scales, a long course of disease, and recurrent attacks. According to traditional Chinese medicine, psoriasis is mainly characterized by blood heat syndrome, blood stasis syndrome and blood dryness syndrome, accounting for more than 90% of all syndrome types. The TCM syndrome differentiation and treatment of psoriasis also attach great importance to the transformation and evolution of TCM syndrome types. For instance, the three syndrome types of blood heat syndrome, blood stasis syndrome and blood dryness syndrome are not static and can transform into each other. For example, blood heat syndrome can develop into blood dryness syndrome as the disease progresses, blood dryness syndrome can transform into blood stasis syndrome, and blood stasis syndrome can also transform into blood heat syndrome or blood dryness syndrome. Observation is an important diagnostic method in traditional Chinese medicine. The images of tongue and face diagnosis contain a lot of important clinical information. They can objectively reflect the prosperity and decline of qi and blood in the human body, the nature of diseases, the depth of the lesion location, the prognosis of the disease, and can also reflect the physiological and pathological changes of the body. In recent years, significant progress has been made in the research of digital and intelligent technologies for tongue and facial diagnosis. Introducing objective indicators such as tongue diagnosis, facial diagnosis and pulse diagnosis into the evaluation research of diseases has become a hot topic. This project, by analyzing the clinical tongue and facial image data of patients with psoriasis vulgaris and combining it with clinical laboratory indicators, fuses and analyzes the characteristic parameters of patients' tongue and facial diagnosis with blood biochemical indicators, metabolomics and other data. This is helpful to reveal the disease occurrence pattern of patients with blood stasis type psoriasis and construct a diagnostic model for blood stasis syndrome of psoriasis. At the same time, it provides a powerful decision support tool for clinical practice and also helps deepen our understanding of the complex process of the occurrence of blood stasis type psoriasis, thereby providing a solid scientific basis for formulating precise diagnostic and treatment strategies.

02

Conditions studied

  • Psoriasis (PsO)
  • Traditional Chinese Medicine (TCM)
  • Diagnosis
03

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

This study intends to select 150 patients with blood stasis syndrome of psoriasis who visited the Department of Dermatology of Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, as well as 150 patients with non-blood stasis syndrome of psoriasis. Additionally, 150 people who visited the hospital due to non-papular psoriasis skin diseases such as eczema or acne, and who were confirmed by professional doctors to have no psoriasis, will be selected as the non-psoriasis subjects.

Inclusion criteria

  • Inclusion criteria for the non-psoriasis subjects: (1) Those who do not meet the Western medical diagnostic criteria for psoriasis; (2) No gender restrictions; 18 years old ≤ age ≤ 65 years old; (3) Understand and agree to participate in this study and sign the informed consent form; Inclusion criteria for the psoriasis blood stasis syndrome group: (1) Those who meet the Western medical diagnostic criteria for psoriasis and whose TCM syndrome classification belongs to blood stasis syndrome; (2) No gender restrictions; 18 years old ≤ age ≤ 65 years old; (3) Understand and agree to participate in this study and sign the informed consent form.

Inclusion criteria for the psoriasis non-blood stasis syndrome group: (1) Those who meet the Western medical diagnostic criteria for psoriasis and whose TCM syndrome classification belongs to blood heat syndrome/blood dryness syndrome; (2) No gender restrictions; 18 years old ≤ age ≤ 65 years old; (3) Understand and agree to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion Criteria:

  • (1) Due to various reasons, the collected tongue and facial images may be unclear or cannot be successfully monitored and analyzed; (2) For those subjects whose facial makeup or tongue coating is applied, the information obtained from tongue and facial diagnosis may be inaccurate.
04

Study design

Observational model
Other
Time perspective
Cross-sectional
Enrollment
450 participants (estimated)
Target follow-up
2 Weeks
Patient registry
Yes
Biospecimen retention
Samples with dna

Groups and cohorts

  • Non-psoriasis subjects

    Who visit for non-psoriasis skin conditions such as eczema or acne, and have been professionallyand confirmed by doctors not to have psoriasis, will be chosen as the Non-psoriasis subjects.

    Other: No intervention

  • Psoriasis blood stasis syndrome group

    Patients with psoriasis diagnosed as having blood stasis syndrome

    Other: No intervention

  • Psoriasis non-blood stasis syndrome group

    Patients with psoriasis diagnosed as not having blood stasis syndrome

    Other: No intervention

Interventions

  • OtherNo intervention

    This is an observational study, no intervention implemented.

05

What researchers measure

Primary outcomes

  1. Images

    Time frame: 1 day (Collect the images of the patient's tongue and face using a tongue surface scanner)

Secondary outcomes

  1. Serum metabolomics data

    Time frame: 1 day (Collect the serum and send it to the testing company for metabolomics testing)

  2. Psoriasis Area and Severity Index (PASI)

    Time frame: The researcher conducted a Psoriasis Area and Severity Index (PASI) assessment on the psoria on the 1 day of sample collection

  3. Inflammatory factor

    Time frame: 1 day (Collect serum and test the levels of IFN-γ, TNF-α and IL-17)

06

Study locations

1 site
  • Shanghai Yueyang Integrated Medicine Hospital
    Shanghai, Shanghai Municipality 200433, China
07

Registry details

Key details

Study ID
NCT07351448
Lead sponsor
Shanghai Yueyang Integrated Medicine Hospital
Responsible party
Sponsor
First posted
Jan 20, 2026
Start date
Jan 20, 2026 (estimated)
Primary completion
Sep 30, 2027 (estimated)
Completion
Sep 30, 2027 (estimated)
Last update
Jan 20, 2026

Study contacts

Xin Li, Doctor
Contact
13661956326@163.com
13661956326
Munsoon Hong, Doctor
Contact
hms2785@naver.com
15502131320

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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