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RecruitingNCT07350330Updated Jan 20, 2026

Comparative Study of Muscle Transplantation Versus Y Splitting Recession Technique in Treatment of Large Angle Exotropia

An interventional study of muscle transplantation and Y splitting in Exotropia, sponsored by Ain Shams University. Recruiting at 1 site in Egypt. Open to participants aged 6 Years and older. Per ClinicalTrials.gov, last updated 2026-01-20.

Sponsored by Ain Shams University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Oct 2025; still recruiting 1 year later.
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
6 Years and older
Sex
All
01

Study summary

This study is designed to correct large-angle exotropia by monocular surgery. It compares two augmented recession techniques, which are recession with muscle transplantation and recession with Y splitting.

02

Conditions studied

  • Exotropia

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03

In context

Exotropia

58 studies on the registry are indexed under Exotropia; 13 are open to participants now.

This study's planned enrollment of 30 is below the median of 50 across 49 interventional studies indexed under Exotropia.

Browse Exotropia studies →

Lead sponsor

Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.

Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
6 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age should be of more than 6 years Exotropia of an angle ranging from 50 to 70 PD Myopic or hypermetropic refraction

Exclusion criteria

Exclusion Criteria:

  • history of previous squint surgery significant vertical deviation incomitant squint in the form of paralytic or restrictive disorder any neurological disease
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
30 participants (estimated)

Study arms

  • Active comparator
    Muscle transplantation

    This group will undergo medial rectus resection, lateral rectus recession, with muscle transplantation

    Procedure: muscle transplantation

  • Active comparator
    Y splitting

    This group will undergo medial rectus resection, lateral rectus recession, with Y splitting

    Procedure: Y splitting

Interventions

  • Proceduremuscle transplantation

    transplanting a resected part of medial rectus to the already recessed lateral rectus muscle

  • ProcedureY splitting

    Y splitting of the recessed lateral rectus muscle

06

What researchers measure

Primary outcomes

  1. Ocular alignment

    To measure ocular alignment using prisms after lateral rectus recession with muscle transplantation versus lateral rectus recession with Y splitting

    Time frame: from the operation till six months postoperatively

Secondary outcomes

  1. palpebral fissure height

    Assess whether this is a change in palpebral fissure height pre- and postoperatively by measurement using a ruler

    Time frame: from preoperative to 6 months postoperative

  2. ocular incomitance

    The presence of ocular incomitance and gaze restriction using prisms and motility tests after surgery

    Time frame: from surgery till 6 months afterward

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Study locations

1 of 1 sites recruiting
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07350330
Responsible party
Sponsor
First posted
Jan 20, 2026
Start date
Oct 30, 2025
Primary completion
Oct 1, 2026 (estimated)
Completion
Dec 30, 2026 (estimated)
Last update
Jan 20, 2026

Study contacts

Alaa mohsen Elmaghraby, masters
Contact
Alaa.Mohsen@med.asu.edu.eg
+201115538151

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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