An observational study in Total Hip Arthroplasty (THA), Total Knee Arthroplasty (TKA) and Hip Osteoarthritis, sponsored by Medical University of Warsaw. Recruiting at 1 site in Poland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-16.
Sponsored by Medical University of Warsaw · Observational
The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative diseases. Determining potential disturbances in the levels or functions of these parameters may in the future contribute to improving treatment - for example, through supplementation of deficient metals or modulation at the immunological level. The main question it aims to answer is:
Are selected rare metals, trace elements and other selected immunological parameters lowered in the tissue of the hip or knee joint as well as in serum in the course of osteoarthritis?
628 studies on the registry are indexed under Osteoarthritis, Hip; 121 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 141 across 154 observational studies indexed under Osteoarthritis, Hip.
Browse Osteoarthritis, Hip studies →Medical University of Warsaw is the lead sponsor of 316 studies on the registry; 87 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients undergoing primary THA or TKA at the trauma and orthopedics department of the hospital in Ostrów Mazowiecka, as well as at the trauma and orthopedics department in Międzylesie Specialist Hospital in Poland.
Exclusion Criteria:
Enzymatic activity of selected proteolytic enzymes in periarticular tissue homogenate (e.g., metalloproteinases and selected serine/cysteine proteases).
Enzymatic activity assessed using biochemical/spectrofluorometric methods and normalized to total protein. Each enzyme will be reported separately. Data is planned to be reported as activity units per mg protein (e.g. U/mg protein).
Time frame: Perioperative/Periprocedural (during primary THA/TKA; index hospitalization)
Protein concentration of selected inflammatory markers in blood (e.g., TNF-α, IL 17α).
Protein concentrations measured by enzyme immunoassays (EIA/ELISA). Each protein will be reported separately as pg/mL.
Time frame: Perioperative/Periprocedural (day of surgery; index hospitalization for primary THA/TKA)
Trace element concentration in periarticular tissues (e.g., Zn, Cu, Fe).
Trace element content measured by Inductively Coupled Plasma - Mass Spectrometry (ICP-MS). Each element will be reported separately. The units for serum measurements is µg/L, and for other tissue is mg/kg dry weight.
Time frame: Perioperative/Periprocedural (day of surgery; index hospitalization for primary THA/TKA)
Relative mRNA expression of selected inflammatory and bone metabolism markers in periarticular tissue (e.g. TNF-α, RANK, RANKL, BMP-12, IL-17α, IL-17αR).
Relative mRNA expression measured by RT-qPCR and reported as fold change (e.g., 2\^-ΔΔCt). Each gene will be reported separately (no aggregation into a single score).
Time frame: Perioperative/Periprocedural (day of surgery; index hospitalization for primary THA/TKA)
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