An interventional study of Haptic stimulation device and Brain MRI in Stroke, Upper Extremity Paresis and Manual Dexterity, sponsored by Centre Hospitalier St Anne. Not yet recruiting at 1 site in France. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-14.
Sponsored by Centre Hospitalier St Anne · Not applicable, Interventional, and Diagnostic
Among 12 studies in Stroke by Centre Hospitalier St Anne — 6 open to participants now, 6 under way, none of them phase 3. Stroke · Centre Hospitalier St Anne.
Among the 12 studies in Stroke by Centre Hospitalier St Anne, this one is the 6th largest by planned enrollment of the 10 interventional ones, is one of 2 that started in 2026, is one of 10 with no phase, and was the 11th registered.
8,255 studies on the registry are indexed under Stroke; 2,056 are open to participants now.
This study's planned enrollment of 90 is above the median of 49 across 6,024 interventional studies indexed under Stroke.
Browse Stroke studies →6 of the 12 studies in Stroke by Centre Hospitalier St Anne are open now, in 1 country. Each count lists the studies.
Of the 1,415 Stroke studies recruiting now, 697 (49%) set no upper age limit and 280 (20%) stop at 75 or younger; 77 take children under 18; 196 take healthy volunteers.
This study: 18 Years to 85 Years · all sexes · healthy volunteers too.
The full table on the hub →12 studies; the count open now beside each. This study's row is marked.
First in 2014; this study’s year is marked. 2 started in 2026.
Median enrollment 107 across the 10 interventional studies, 180 across the 2 observational. Of the 4 that completed or were terminated, 0 (0%) have results posted.
Centre Hospitalier St Anne is the lead sponsor of 101 studies on the registry; 55 are open to participants now.
None of the studies under way reaches primary completion within a year.
Among the 12 studies in Stroke by Centre Hospitalier St Anne, from their registry updates:
In the proposed research, we will assess motor and sensory functions of the hand using clinical tests and a tool designed to measure manual dexterity combined with vibrotactile stimulation. We will also evaluate the integrity of brain structure and function using MRI.
In this study, 90 post-stroke patients will be followed over three visits at 3 weeks, 3 months, and 6 months after stroke. Manual dexterity will be assessed using the Dextrain Manipulandum, both with and without the addition of finger vibrations. These vibrations will be delivered using vibratory rings, a tool that has been developed and is currently being validated in healthy participants and in patients with chronic post-stroke conditions. These measurements will allow us to quantify haptic facilitation, that is the impact of adding finger vibrations on hand motor function.
During each of the three visits, we will also administer validated sensory, motor, and cognitive clinical assessments, as well as anatomical, resting-state functional, and diffusion MRI sequences to investigate brain structure and function in relation to this haptic facilitation. These longitudinal measurements will enable the development of biomarkers of motor recovery of manual dexterity after stroke, with the primary objective of improving the prediction of dexterity recovery using a regression model.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients will be followed for 6 months over three visits. They will undergo validated sensory, motor, and cognitive clinical assessments, as well as MRI scans and manual dexterity tests performed with and without the addition of vibratory stimulation to the fingers, using a tool previously developed as part of this project.
Device: Haptic stimulation device · Other: Brain MRI
Healthy control participants will be assessed during a single visit. They will undergo motor, sensory, and cognitive clinical assessments, as well as manual dexterity tasks performed with and without the addition of finger vibrations using a previously developed tool. They will also undergo anatomical, resting-state functional, and diffusion brain MRI sequences. Each healthy participant will be matched to a patient in terms of age, sex, and handedness of the affected limb. For example, if we include a 60-year-old male post-stroke patient who is right-handed and has a right upper-limb impairment, we will include a healthy male participant aged 60 ± 5 years who is also right-handed.
Device: Haptic stimulation device · Other: Brain MRI
Both patients and healthy participants will perform manual dexterity tasks using the Dextrain Manipulandum. In addition, they will receive finger vibrations delivered via rings that we have previously developed. These vibrations will have a frequency of 150 Hz and will be delivered for a duration of 150 ms.
Subjects and patients will undergo anatomical, resting-state functional, and diffusion brain MRI sequences.
Gain in the prediction of manual dexterity recovery
The primary outcome measure is a 10% improvement in the prediction of the Box and Block Test (BBT) score at 3 and 6 months post-stroke achieved by adding the haptic effect to a multivariate model.
Time frame: 3 months post enrollment
Change in the prediction of the Box and Block Test (BBT) score when taking into account the haptic effect during an index finger force control task.
Determine whether the haptic effect calculated during an index finger force control exercise (using the dextrain manipulandum) measured in the acute phase after stroke can improve the prediction of manual dexterity recovery (Box and Blocks Test, BBT) at 3 months and 6 months after stroke.
Time frame: 3 and 6 months post enrollment
Predicting recovery in various clinical tests of motor and sensory function and activity limitations at 3 months and 6 months post-stroke.
Determine whether the haptic effect VS absence of haptic effect improves the prediction of recovery from motor impairment (Fugl Mayer Assessment for Upper Extremity FMA-UE, Purdue Pegboard Test), sensitivity (monofilaments and Nottingham Sensory Assessment), and activity limitations (Stroke Impact Scale) of the upper limb from 3 weeks to 3 and 6 months post-stroke.
Time frame: 3 and 6 months post enrollment
Difference in functional and structural connectivity between subgroups with vs without haptic effect at 3 and 6 months
Investigate whether connectivity of fronto-parietal networks at 3 weeks post-stroke predicts recovery of haptic effect and dexterity at 3 and 6 months.
Time frame: 3 and 6 months post enrollement
Changes in the structural and functional connectivity of fronto-parietal networks between 3 weeks and 6 months post-stroke
A difference in the change in connectivity between subgroups with versus without haptic effect at 6 months will be investigated.
Time frame: 3 and 6 months post stroke
Difference in brain connectivity between brain images of healthy subjects and patients 3 weeks post-stroke and healthy subjects and patients 6 months post-stroke.
Compare brain connectivity between the group of healthy subjects and the group of patients at 3 weeks and 6 months post-stroke.
Time frame: 6 months post enrollement
Correlation between the location of the lesion at 3 weeks and the haptic effect and the results of clinical tests
These correlations will be done using Voxel Based Lesion Symptoms Mapping technique (VLSM)
Time frame: 3 and 6 months post stroke
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Mar 2026; primary completion for Mar 2028, 24 months later.
Of 3,108 non-industry interventional studies with no phase under Stroke, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 46. This study's planned 24 months is close to that.
Counting every sponsor, half of 3,252 studies reached it within 23 months; a quarter within 10 and three quarters within 46.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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