An observational study in Dental Trauma, sponsored by University of Pisa. Active, not recruiting at 1 site in Italy. Per ClinicalTrials.gov, last updated 2026-01-12.
Sponsored by University of Pisa · Observational
Dental traumatology is a field of dentistry , especially in pediatric age, but also in adulthood with permanent dentition. Dental trauma has a higher incidence in preschool, school-age, and adolescent patients, accounting for about 5% of injuries for which the intervention of a specialist physician is required. Traumatic avulsion of permanent teeth accounts up to 0.5-16% of all dental injuries and is considered one of the true emergencies in dentistry.The treatment of choice in case of traumatic avulsion of permanent teeth is the quickest-as-possible replantation. The primary objectives of this prospective study were to evaluate the incidence of complications and survival rates of replanted teeth over time. The secondary objectives were to assess and to examine the correlation between the development of complications and factors such as extra-oral time, storage media, root maturity and the presence of alveolar fractures.
2,217 studies on the registry are indexed under Wounds and Injuries; 441 are open to participants now.
This study's enrollment of 13 is below the median of 169 across 690 observational studies indexed under Wounds and Injuries.
Browse Wounds and Injuries studies →University of Pisa is the lead sponsor of 113 studies on the registry; 28 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All adult and pediatric patients who experienced a traumatic avulsion of one or more permanent teeth and were treated at the University Hospital of Pisa
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion criteria
- Patients with absolute to dental replantation
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adult and pediatric patients who experienced a traumatic avulsion of one or more permanent teeth
Other: Tooth replantation
Avulsed teeth were replanted according to the International Academy of Dental Traumatology guidelines (IADT)
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following IADT guidelines.
Time frame: 2 weeks after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 4 weeks after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 3 months after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 6 months after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 12 months after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 24 months after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 36 months after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 48 months after trauma
Tooth survival
Tooth survival was defined as the presence of the tooth in the oral cavity at the time of follow-up. Tooth survival is assessed at each follow-up visit after replantation following the IADT guidelines.
Time frame: 60 months after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 2 weeks after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 4 weeks after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 3 months after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 6 months after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 12 months after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 24 months after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 36 months after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 48 months after trauma
Incidence of complications
Evaluated as presence/absence of a dental complication following trauma.
Time frame: 60 months after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 2 weeks after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 4 weeks after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 3 months after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 6 months after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 12 months after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 24 months after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 36 months after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 48 months after trauma
Dental mobility
Tooth mobility clinically evaluated from 0 to 3
Time frame: 60 months after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 2 weeks after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 4 weeks after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 3 months after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 6 months after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 12 months after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 24 months after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 36 months after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 48 months after trauma
Complication - root resorption
Radiographic signs of root resorption
Time frame: 60 months after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 2 weeks after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 4 weeks after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 3 months after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 6 months after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 12 months after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 24 months after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 36 months after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 48 months after trauma
Complication - ankylosis
Clinical and radiographic signs of ankylosis (loss of periodontal space, absence of physiological tooth mobility)
Time frame: 60 months after trauma
Extra-oral time
Evaluated in minutes from the avulsion to the replantation
Time frame: At baseline (toorh replantation after avulsion)
Storage medium
Storage medium of the avulsed tooth (milk, water, saline, etc)
Time frame: At baseline (tooth replantation following avulsion)
Alveolar fracture
Presence of alveolar fractures associated to tooth avulsion
Time frame: At baseline (tooth replantation following avulsion)
Plan to share: No
No publications or documents are linked to this record.
Ran from Nov 2020 to primary completion in Nov 2025, 60 months.
Of 265 non-industry observational studies under Wounds and Injuries, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 60. This study's 60 months is above that.
Counting every sponsor, half of 312 studies reached it within 28 months; a quarter within 12 and three quarters within 60.
Wounds and Injuries covers many different conditions, not one, so the studies compared here vary widely. Read these figures as a rough guide.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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