An interventional study of Oocyte quality assessment using spectrophotometer in Oocyte Quality Assessment Using Spectrophotometer, sponsored by Hillel Yaffe Medical Center. Active, not recruiting at 1 site in Israel. Open to female participants. Per ClinicalTrials.gov, last updated 2026-01-09.
Sponsored by Hillel Yaffe Medical Center · Not applicable, Interventional, and Screening
The aim of the study is to check whether follicular fluid evaluation using a spectrophotometer can differentiate high quality oocytes from low quality oocytes. Oocyte quality will be defined using GDF9, BMP15 and oocyte morphology. The correlation between cortisol levels in women and oocyte quality parameters will be estimated.
Hillel Yaffe Medical Center is the lead sponsor of 301 studies on the registry; 10 are open to participants now.
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Procedure: Oocyte quality assessment using spectrophotometer
On the OPU (ovum pick-up) day the following blood biochemical markers will be measured as well- Blood interleukins 1-6, cytokine, hormone profile, lipid profile, cortisol. After collecting the oocytes- the Follicular fluid will be sent for the following tests- 1. mid-infrared spectrometry, 2. P, E2, testosterone, cortisol, cytokines, IL 1-6, lipids, fatty acids. 3. BMP-15, GDF-9 and HSPG2 4. GCMS-Gas Chromatography Mass Spectrophotometer
Difference in follicular fluid infrared spectrophotometric profiles between high-quality and low-quality oocytes.
Infrared spectrophotometric measurements of follicular fluid collected at oocyte retrieval will be obtained using attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR). Oocytes will be classified as high-quality or low-quality based on predefined morphological criteria and follicular fluid levels of GDF9 and BMP15 measured by ELISA. The primary outcome will be reported as differences in normalized spectral absorbance features between the two oocyte quality groups, including discrimination performance using multivariate analysis.
Time frame: 3 Years
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Hillel Yaffe Medical Center