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RecruitingNCT07325175Updated Oct 20, 2026

Quantifying Motor Network Dynamics to Predict and Enhance Outcomes in Pediatric Dystonia

An interventional study of DBS in Dystonia, Pediatric and Deep Brain Stimulation, sponsored by Children's Hospital Medical Center, Cincinnati. Recruiting at 1 site in United States. Open to participants aged 6 Years to 21 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-20.

Sponsored by Children's Hospital Medical Center, Cincinnati · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Started Sep 2026; still recruiting 2 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
75
Allocation
Not applicable
Ages
6 Years to 21 Years
Sex
All
01

Study summary

The goal of this study is to understand the development and progression of childhood dystonia, a movement disorder, in children. The main questions it aims to answer are:

How does the activity of the neural network evolve in children with dystonia in the context of motor development? What are the effects of chronic and active stimulation on cortical and subcortical motor network function in children with deep brain stimulation (DBS)?

Participants will:

  • Undergo noninvasive electrophysiological measurements (EEG, EMG) to quantify neural network activity. They will be tested at rest and during a simple motor reaction task.
  • Children with DBS will be assessed in the on and off DBS state to assess effects of chronic and active changes in motor network function.
02

Conditions studied

  • Dystonia
  • Pediatric
  • Deep Brain Stimulation
  • Motor Development

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03

In context

Dystonia

213 studies on the registry are indexed under Dystonia; 54 are open to participants now.

This study's planned enrollment of 75 is above the median of 28 across 114 interventional studies indexed under Dystonia.

Browse Dystonia studies →

Lead sponsor

Children's Hospital Medical Center, Cincinnati is the lead sponsor of 673 studies on the registry; 130 are open to participants now.

Of its 57 completed or terminated interventional studies of FDA-regulated products, 31 (54%) have results posted.

Browse Children's Hospital Medical Center, Cincinnati studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
6 Years to 21 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • For dystonia subjects:
  • Dx of dystonia (with and without DBS)
  • willingness and ability to complete study protocols.
  • For Typically Developing Controls:
  • normal developmental milestones
  • absence of any neuropsychiatric disorder
  • no significant medical condition.

Exclusion criteria

Exclusion Criteria:

  • history of epilepsy
  • presence of implanted medical devices (except DBS in dystonia subjects)
  • lack of cognitive or physical ability to complete study protocol.
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
75 participants (estimated)

Study arms

  • Experimental
    DBS

    Patients with DBS will complete neurophysiological recordings with DBS on and off

    Device: DBS

Interventions

  • DeviceDBS

    Subjects with DBS will complete protocol with and without active stimulation

06

What researchers measure

Primary outcomes

  1. Longitudinal change in Motor Network Aperiodic Activity

    Time frame: -Baseline -Through study completion, an average of 2 years

Secondary outcomes

  1. Longitudinal change in Motor Network Periodic Activity

    Time frame: -Baseline -Through study completion, an average of 2 years

  2. Longitudinal change in Motor Network EEG connectivity

    Time frame: -Baseline -Through study completion, an average of 2 years

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: Yes — Available upon reasonable request and discussion

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Sep 2026 (actual). Primary completion is estimated for Aug 2031, 59 months after the start.

Of 48 non-industry interventional studies with no phase under Dystonia, half reached primary completion within 50 months of starting (the median), counting those still running; a quarter within 26 and three quarters within 75. This study's planned 59 months is above that.

Counting every sponsor, half of 49 studies reached it within 50 months; a quarter within 26 and three quarters within 75.

How these figures are worked out, and which studies are left out of them.

Registered
Jan 6, 2026
First posted
Jan 8, 2026
StartActual
Sep 1, 2026
Primary completionEst.
Aug 31, 2031
CompletionEst.
Aug 31, 2031
Last update
Oct 20, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Minor edits
Nothing that changes what the study is or who can join. Edited: verification date and date precision
1 update, last Oct 20, 2026
Show all 1 update
  1. Oct 20, 2026
    Minor edits only
    + 2 other changes: verification date and date precision

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07325175
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
Responsible party
Travis Larsh (Assistant Professor, Children's Hospital Medical Center, Cincinnati) — Principal investigator
First posted
Jan 8, 2026
Start date
Sep 1, 2026
Primary completion
Aug 31, 2031 (estimated)
Completion
Aug 31, 2031 (estimated)
Last update
Oct 20, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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Discussion

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