An interventional study of Garlic Lettuce Fermented Powder and Placebo in Mild Cognitive Impairment (MCI), sponsored by Pusan National University Yangsan Hospital. Active, not recruiting at 1 site in South Korea. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-01-12.
Sponsored by Pusan National University Yangsan Hospital · Not applicable, Interventional, and Treatment
"This study aims to investigate the cognitive and psychological changes in adults with mild cognitive impairment (K-MoCA scores between 16 and 23) following daily consumption of fermented garlic lettuce powder for 2 months
3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's enrollment of 60 is close to the median of 65 across 2,808 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →Pusan National University Yangsan Hospital is the lead sponsor of 106 studies on the registry; 27 are open to participants now.
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Exclusion Criteria:
Participants receive fermented garlic lettuce powder, administered orally as three tablets per day for 2 months (total of 180 tablets).
Dietary Supplement: Garlic Lettuce Fermented Powder
Participants take 1 placebo tablet daily for 2 months, totaling 60 tablets
Other: Placebo
The Garlic Lettuce Fermented Powder tablets (intervention group) are taken 3 tablets daily for 2 months, totaling 180 tablets
Participants take 1 placebo tablet daily for 2 months, totaling 60 tablets
K-MoCA
The Korean version of the Montreal Cognitive Assessment (K-MoCA) is a cognitive screening tool with scores ranging from 0 to 30, with higher scores indicating better cognitive function. The outcome measure is the change in K-MoCA score.
Time frame: Assessments are performed at baseline and at 2 months.
SVLT
The Seoul Verbal Learning Test (SVLT) is a neuropsychological assessment tool used to evaluate verbal memory performance. Scores range from 0 to 36, with higher scores indicating better memory function.
Time frame: Assessments are performed at baseline and at 2 months.
KCWS
The Korean Color-Word Stroop Test (KCWS) is a neuropsychological assessment used to evaluate executive function and cognitive control. Performance is measured by the number of correct responses within 1- and 2-minute intervals, with higher scores indicating better cognitive function.
Time frame: Assessments are performed at baseline and at 2 months.
RCFT
The Rey Complex Figure Test (RCFT) is a neuropsychological assessment used to evaluate visuospatial constructional ability and visual memory. Scores range from 0 to 36, with higher scores indicating better memory performance.
Time frame: Assessments are performed at baseline and at 2 months.
DST
The Digit Span Test (DST) is a neuropsychological assessment used to evaluate attention and working memory. Scores range from 0 to 24, with higher scores indicating better concentration and attention.
Time frame: Assessments are performed at baseline and at 2 months.
COWAT
The Controlled Oral Word Association Test (COWAT) is a neuropsychological assessment used to evaluate verbal fluency and executive function. Scores range from 0 to 27, with higher scores indicating better verbal fluency, executive function, attention, and problem-solving abilities.
Time frame: Assessments are performed at baseline and at 2 months.
BDI
The Beck Depression Inventory (BDI) is a self-report questionnaire used to assess the severity of depressive symptoms. Each item is scored from 0 to 3, with total scores ranging from 0 to 63, where higher scores indicate more severe depressive symptoms.
Time frame: Assessments are performed at baseline and at 2 months.
EQ-5D
The EuroQol-5 Dimension (EQ-5D) is a standardized instrument for measuring health-related quality of life. Scores range from 0 to 100, with lower scores indicating better perceived health status and higher scores reflecting more severe health problems.
Time frame: Assessments are performed at baseline and at 2 months.
MFS
The Multidimensional Fatigue Scale (MFS) is a self-report questionnaire used to assess fatigue across multiple dimensions. Each dimension is rated from 0 to 20, with a total score ranging from 0 to 100. Lower scores indicate less fatigue, while higher scores reflect more severe fatigue.
Time frame: Assessments are performed at baseline and at 2 months.
PWI-SF
The Psychological Well-Being Index-Short Form (PWI-SF) is a self-report questionnaire used to assess psychological well-being. Each dimension is rated from 0 to 20, with total scores ranging from 0 to 54, where higher scores indicate better psychological well-being, life satisfaction, and emotional stability.
Time frame: Assessments are performed at baseline and at 2 months.
LSEQ
The Leeds Sleep Evaluation Questionnaire (LSEQ) is a self-report instrument used to assess subjective sleep quality. Scores are based on a scale from 0 to 100, with higher scores indicating better sleep quality and lower scores reflecting greater sleep disturbance.
Time frame: Assessments are performed at baseline and at 2 months.
Plan to share: No
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This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Pusan National University Yangsan Hospital