CClinicalTrials.gg
Active, not recruitingNCT07319728Updated Jan 6, 2026

Novel Transdermal Ketoprofen Gel Formulation for Knee Osteoarthritis

A Phase 1 interventional study of ketoprofen and ketoprofen in Knee Osteoarthritis, sponsored by New Valley University. Active, not recruiting at 1 site in Egypt. Open to participants aged 45 Years and older. Per ClinicalTrials.gov, last updated 2026-01-06.

Sponsored by New Valley University · Phase 1, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Jan 2026, 9 months ago, but the record still lists the study as active, not recruiting.
  • Registered 7 months after the study started (first participant enrolled May 2025, registered Dec 2025).
Phase
Phase 1
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
45 Years and older
Sex
All
01

Study summary

A single blind randomized controlled clinical study

Read the detailed description

A single blind randomized controlled clinical study

02

Conditions studied

  • Knee Osteoarthritis

Keywords

  • knee joint osteoarthritis
  • Transdermal Ketoprofen Gel
03

In context

Osteoarthritis, Knee

3,302 studies on the registry are indexed under Osteoarthritis, Knee; 608 are open to participants now.

This study's enrollment of 40 is below the median of 70 across 2,731 interventional studies indexed under Osteoarthritis, Knee.

Browse Osteoarthritis, Knee studies →

Lead sponsor

New Valley University is the lead sponsor of 23 studies on the registry; 12 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patient diagnosed with osteoarthritis in knee by:

Full history taking Physical examination including (joint tenderness, swelling, crepitus and limitation of motion).

Exclusion criteria

Exclusion Criteria:

  • 1. Patients with dual diagnosis 2. Patients have skin lesion or dermatologic disease in the treatment area
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
40 participants (actual)

Study arms

  • Experimental
    formulation arm

    new formulation of ketoprofen

    Drug: ketoprofen

  • Active comparator
    commercial product

    positive control receiving commercial product

    Drug: ketoprofen

Interventions

  • Drugketoprofen

    new gel formulation

  • Drugketoprofen

    commercial gel

06

What researchers measure

Primary outcomes

  1. Visual Analogue Scale (VAS)

    Time frame: 2 weeks

  2. McMaster Universities Arthritis Index (WOMAC)

    Time frame: 2 weeks

07

Study locations

1 site
  • Minia University
    Minya, Minya Governorate 11666, Egypt
08

References and documents

Publications

  • Wang Y, Fan M, Wang H, You Y, Wei C, Liu M, Luo A, Xu X, Duan X. Relative safety and efficacy of topical and oral NSAIDs in the treatment of osteoarthritis: A systematic review and meta-analysis. Medicine (Baltimore). 2022 Sep 9;101(36):e30354. doi: 10.1097/MD.0000000000030354. PubMed 36086745 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 6, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07319728
Lead sponsor
New Valley University
Responsible party
Asmaa Ahmed Hamed Mohie Eldin (Associate professor Clinical pharmacy department, New Valley University) — Principal investigator
First posted
Jan 6, 2026
Start date
May 10, 2025
Primary completion
Jan 2026 (estimated)
Completion
Feb 2026 (estimated)
Last update
Jan 6, 2026

Study contacts

Sara A Hassan
principal investigator · Badr University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion