IGNITE-TX Phase III: (Identifying Individuals for Genetic Testing & Treatment) Intervention

Probands:

1. 18 years of age or older
2. Speaks and reads English or Spanish
3. Resides in the United States
4. Has a pathogenic or suspected pathogenic variant in BRCA1, BRCA2, MLH1, MSH2/EPCAM, MSH6, or PMS2*
5. Has access to the internet or phone and can send and receive email and/or text messages at a US telephone number.

6. Attests to have at least one at-risk relative who meets inclusion criteria for first-degree relative

   • For cancer patients who are unaware of their mutation status, we will share existing local and national genetics resources, like those provided in the usual care family letter.

At-Risk Relatives (ARR):

1. 18 years of age or older
2. Speaks and reads English or Spanish
3. Resides in the United States
4. Has a first or second degree relative who has a deleterious/suspected deleterious HBOC or LS variant present
5. Has access to internet or phone and can send and receive email and/or text messages at a US telephone number

SAB:

1. Eligible SAB will include any groups connected to HBOC or Lynch syndrome, including those that focus on underserved populations or specific ethnic communities.

Clinicians:

1. Eligible clinicians will include gynecologic oncologists, general gynecologists, medical oncologists, and advanced practice providers who interact with individuals diagnosed with HBOC or Lynch syndrome and/or their at-risk relatives.

Exclusion Criteria:

Probands:

1. Has no eligible at-risk relatives (ARRs) or is unable/unwilling to provide their contact information
2. Has negative germline genetic testing or only variant of uncertain significance
3. Unwilling or unable to provide consent

At-Risk Relatives (ARR):

1. Unwilling or unable to provide consent
2. Reports no known HBOC or LS variant within the family
3. Has already been tested for the variant identified in the proband
4. Already listed as an ARR for another proband

SAB:

1. SAB members will be excluded if they are not connected to HBOC or Lynch syndrome-related groups or if their organizations do not focus on these conditions or the communities impacted by them.

Clinicians:

1. Clinicians will be excluded if they do not provide direct care to individuals diagnosed with HBOC or Lynch syndrome or their at-risk relatives, or if they do not practice within the specified eligible clinician roles.