An interventional study of TRE and ProtAM TRE in Generally Healthy Adults Over 60 Years Old, sponsored by University of Surrey. Recruiting at 1 site in United Kingdom. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-02.
Sponsored by University of Surrey · Not applicable, Interventional, and Treatment
The aim this study is to investigate the effects of time-restricted eating (TRE) on body composition, muscle function and markers of metabolic health of adults over 60 years old. This study will compare different variations of TRE - with and without an additional protein.
This study involves attending two study days at the University of Surrey for baseline and end-of-intervention measurement of body composition using a gold-standard dual energy x-ray absorptiometry (DEXA) scan; muscle function using hand grip strength and 30-second sit-to-stand tests; weight. A blood sample will be taken at each study visit to measure markers of lipid and glucose control, and insulin sensitivity.
Participants will be randomly allocated to one of four study groups:
University of Surrey is the lead sponsor of 91 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Any of the following present (in line with exclusion criteria used in previous TRE research in older adults):
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants undertaking the TRE intervention
Other: TRE
Participants undertaking the ProtAM TRE intervention
Other: ProtAM TRE
Participants undertaking the ProtPM TRE intervention
Other: ProtPM TRE
* Participants will be asked to follow a 16:8 TRE protocol, consuming all their daily within 8 hours, between 12 and 8pm, and fast for 16 hours overnight. * Outside of the eating window, participants will be allowed to consume energy-free drinks only, i.e. water, black tea/coffee, 0-calorie soft drinks.
* Participants will be asked to follow a 16:8 TRE protocol, consuming all their daily within 8 hours, between 12 and 8pm, and fast for 16 hours overnight. * Outside of the eating window, participants will be allowed to consume energy-free drinks only, i.e. water, black tea/coffee, 0-calorie soft drinks. * In addition, they will be asked to consume a protein drink containing 30g protein in the morning, 2 hours before the 8-hour eating window opens at 12pm (i.e. at 10am).
Also known as: TRE + morning protein 'snack'
* Participants will be asked to follow a 16:8 TRE protocol, consuming all their daily within 8 hours, between 12 and 8pm, and fast for 16 hours overnight. * Outside of the eating window, participants will be allowed to consume energy-free drinks only, i.e. water, black tea/coffee, 0-calorie soft drinks. * In addition, they will be asked to consume a protein drink containing 30g protein in the afternoon, either 2 hours after their first meal or 2 hours before their last meal of the day.
Also known as: TRE + afternoon protein 'snack'
Change from baseline in body composition at 2 months using whole-body dual-energy x-ray absorptiometry (DEXA)
Measured using whole-body dual-energy x-ray absorptiometry (DEXA) In addition to the above, body composition will also be assessed using Tanita Bioelectrical impedance analysis (BIA). Fat free and fat mass will be reported in kg.
Time frame: For 8 weeks of the assigned study intervention
Change from baseline in muscle function at 2 months
Measured using grip strength
Time frame: At the start and end of 8 weeks of the assigned study intervention
Change from baseline in muscle function at 2 months
Measured using 30-second sit-to-stand test.
Time frame: At the start and end of 8 weeks of the assigned study intervention
Change in fasting glucose control indicators
HbA1c
Time frame: At the start and end of 8 weeks of the assigned study intervention
Change from baseline in insulin sensitivity at 2 months
HOMA-IR
Time frame: At the start and end of 8 weeks of the assigned study intervention
Change from baseline in lipid metabolism at 2 months
fasting total, LDL- and HDL cholesterol and triglyerides
Time frame: At the start and end of 8 weeks of the assigned study intervention
Change from baseline in diet composition at 2 months
Macro- and micronutrient analysis using the nutrition analysis platform Nutritics of 3-day food diaries administered at the start, mid-point and end of the assigned study intervention.
Time frame: At the start, mid-point (week 4) and end of 8 weeks of the assigned study intervention
Feasibility of the assigned TRE intervention
semi-structured interviews
Time frame: at the end of the 8 week intervention
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No — Not required or applicable for this study protocol
Start is estimated for Dec 2025; primary completion for Jun 2027, 18 months later.
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University of Surrey