An interventional study of Baseline and Installation of high flow humidified air cannula in Ventilated Patients, sponsored by Assistance Publique - Hôpitaux de Paris. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-29.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Treatment
The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.
Nasal stimulation is generated by breathing, which enables olfaction and helps to rhythm brain activity. The loss of nasal stimulation in tracheotomized patients who are dependent on mechanical ventilation may negatively affect respiratory drive and contribute to dyspnea. Restoring nasal airflow therefore emerges as an attractive non-pharmacological approach to treat dyspnea in patients undergoing mechanical ventilation weaning.
The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.
Exclusion Criteria:
Baseline ventilator settings under pressure support
Procedure: Baseline · Procedure: Installation of high flow humidified air cannula · Procedure: Nasal air puffs · Procedure: propeller fan (FAN)
patient ventilated through the tracheostomy with initial ventilator settings
Installation of high flow humidified air cannula with inspired oxygen fraction (FiO2) 21%
Nasal air puffs synchronized with the inspiratory time of the ventilator
Stand-alone fan at the bedside directed toward the face of the patient
Dyspnea
visual analogical scale
Time frame: minute 20
airway occlusion pressure
visual analogical scale
Time frame: minute 20
end expiratory occlusion pressure
visual analogical scale
Time frame: minute 20
respiratory electromyogram (EMG)
visual analogical scale
Time frame: minute 20
tolerance
visual analogical scale
Time frame: minute 20
Plan to share: Yes — The procedures carried out with the French data privacy authority (CNIL, Commission nationale de l'informatique et des libertés) do not provide for the transmission of the database, nor do the information and consent documents signed by the patients. Consultation by the editorial board or interested researchers of individual participant data that underlie the results reported in the article after deidentification may nevertheless be considered, subject to prior determination of the terms and conditions of such consultation and in respect for compliance with the applicable regulations
Supporting information: Study protocol, Icf
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Assistance Publique - Hôpitaux de Paris