An interventional study of ACQUISS protocol assessing emotional processing. in Intellectual Developmental Disorder, sponsored by Hôpital le Vinatier. Recruiting at 1 site in France. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-04-01.
Sponsored by Hôpital le Vinatier · Not applicable, Interventional, and Basic science
Emotions play a crucial part in the quality of life, interpersonal relationships and mental health in general. In adults presenting with intellectual developmental disorder (IDD), emotional abilities may be hindered, thus leading to more challenging behaviors. A better understanding of emotional processes of adults with IDD may help improve the efficiency of behavioral interventions and better improve their quality of life.
The primary goal of this study is to better characterize the abilities and weaknesses of adults with IDD concerning their emotional processes, in comparison to a healthy population. The secondary goals are :
The study will be carried out in 3 steps :
Step 1: All participants will undergo tests to evaluate their intellectual abilities, and auditory and visual screening tests.
Step 2 : All participants will undergo neuropsychological tests assessing attentional and oculomotor abilities (1 hour). During this time, the participant's family member will complete the questionnaires assessing behavior.
Step 3 : All participants will undergo the experimental ACQUISS protocol (task 1 : faces; task 2 : faces in context; task 3 : prosody) (1 hour).
Detailed Description:
Step 1 :
During this first step, all participants (both groups), will undergo the Raven Progressive Matrices (John and Raven 2003) to assess their intellectual abilities. They will then undergo an auditory screening test (tonality test) and a visual screening task (the Rossano-Weiss scale and the Palettes de Léa Grattins task).
Step 2 :
During this second step, all participants (both groups) will undergo :
- 2 cancellation tests from the EVA battery (Chokron, 2010):
Step 3:
During this step, all participants from both groups will undergo the ACQUISS protocol.
387 studies on the registry are indexed under Intellectual Disability; 105 are open to participants now.
This study's planned enrollment of 60 is close to the median of 58 across 248 interventional studies indexed under Intellectual Disability.
Browse Intellectual Disability studies →Hôpital le Vinatier is the lead sponsor of 106 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
IDD group :
Control group :
Exclusion Criteria:
IDD group :
Control group :
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
adults with Intellectual Developmental Disorder
Other: ACQUISS protocol assessing emotional processing.
healthy adults
Other: ACQUISS protocol assessing emotional processing.
Task 1: 5 minute facial emotion recognition test to identify isolated facial expressions. 6 drawn faces, without gender bias, without hair, expressing the 6 universal emotions will be presented. The emotions are: happiness, sadness, anger, fear, surprise and disgust. Task 2 : identifying a character's emotion in a social context (20 min). The subject is presented with drawn social contexts, one character is always in orange, and the face is left blank. The subject then has to choose amongst 6 emotions (happiness, sadness, anger, fear, surprise and disgust) which one would correspond the most to the emotion expressed by the character in orange. Task 3 : recognizing vocal emotions (15 min). The subject is presented with dialogues of 3 sentences. The 3 sentences are expressed with a vocal emotion (same emotion for the 3 sentences). The contents of the sentences are neutral At the end of each dialogue, the subject has to show which emotion was expressed.
proportion of correct answers on the ACQUISS battery
proportion of correct answers in each of the 3 tasks
Time frame: Baseline
Proportion of correct answers on the Entangled lines test
Time frame: Baseline
Proportion of correct answers on the NSUCO test
Northeastern State University College of Optometry test.
Time frame: Baseline
Proportion of correct answers on an auditory attentional task (NEPSY-II)
Time frame: Baseline
Proportion of correct signs barred on the TeddyBear task
Time frame: Baseline
Proportion of correct signs barred on the letter task
Time frame: Baseline
Score on the Agressivity questionnaire
Score on the Agressivity questionnaire ("Problematic behavior in group settings"), filled in by a caregiver. Minimum score = 6; Maximum score = 30. Higher scores suggest greater agressivity.
Time frame: Baseline
Score on the Aberrant Behavior Checklist
Score on the Aberrant Behavior Checklist, filled in by a caregiver. Minimum = 0; Maximum = 174. Higher scores reflect more severe levels of challenging behavior.
Time frame: Baseline
Plan to share: Undecided
No publications or documents are linked to this record.
Started Feb 2026 (actual). Primary completion is estimated for Aug 2028, 30 months after the start.
Of 155 non-industry interventional studies with no phase under Intellectual Disability, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's planned 30 months is above that.
Counting every sponsor, half of 158 studies reached it within 19 months; a quarter within 7 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
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