A Phase 4 interventional study of 3% diquafosol (right eye) and 2% rebamipide (left eye) and 2% rebamipide (right eye) and 3% diquafosol (left eye) in Dry Eye Disease (DED), sponsored by Korea University Anam Hospital. Completed at 1 site in South Korea. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2025-12-22.
Sponsored by Korea University Anam Hospital · Phase 4, Interventional, and Treatment
This study compares the immediate therapeutic and mucin-secreting effects 30 minutes after instillation of 3% diquafosol and 2% rebamipide in dry eye disease.
1,292 studies on the registry are indexed under Dry Eye Syndromes; 192 are open to participants now.
This study's enrollment of 30 is below the median of 60 across 1,077 interventional studies indexed under Dry Eye Syndromes.
Browse Dry Eye Syndromes studies →Korea University Anam Hospital is the lead sponsor of 110 studies on the registry; 29 are open to participants now.
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Exclusion Criteria:
This is a paired-eye design study. Patients were randomly assigned to receive 3% diquafosol in the right eye and 2% rebamipide in the contralateral left eye, with the treatment assignment blinded to the examiner and patients.
Drug: 3% diquafosol (right eye) and 2% rebamipide (left eye)
This is a paired-eye design study. Patients were randomly assigned to receive 3% diquafosol in the left eye and 2% rebamipide in the contralateral right eye, with the treatment assignment blinded to the examiner and patients.
Drug: 2% rebamipide (right eye) and 3% diquafosol (left eye)
3% diquafosol was instilled in the right eye and 2% rebamipide in the left eye.
2% rebamipide was instilled in the right eye and 3% diquafosol in the left eye.
visual analog scale (VAS) score
Unit: points
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
tear breakup time (TBUT)
Unit: Seconds
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
ocular staining score (OSS)
National Eye Institute Scale, 0-15
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
tear meniscus height (TMH)
Unit: mm
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
lipid layer thickenss (LLT)
Unit: nm
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
corneal sensitivity (esthesiometer)
Unit: mm
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
tear MUC1 concentration
measured using enzyme-linked immunosorbent assay (ELISA)
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
tear MUC5AC concentration
measured using enzyme-linked immunosorbent assay (ELISA)
Time frame: Before instillation of eyedrops, and 30 minutes after instillation of eyedrops
Plan to share: No — The data that support the findings of this study are not openly available due to reasons of sensitivity and may available from the corresponding author upon reasonable request.
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.
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Korea University Anam Hospital