An interventional study of Sevoflurane and Desflurane in Perioperative Respiratory Mechanics, sponsored by Konya City Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by Konya City Hospital · Not applicable, Interventional, and Prevention
This single-center, prospective, randomized, assessor-blinded clinical trial aims to compare the effects of sevoflurane and desflurane anesthesia on intraoperative mechanical power in adult patients undergoing elective laparoscopic cholecystectomy. Mechanical power will be measured at three standardized time points using a validated formula, and secondary outcomes include driving pressure values and early postoperative respiratory complications (desaturation, laryngospasm, bronchospasm, cough).
Konya City Hospital is the lead sponsor of 76 studies on the registry; 21 are open to participants now.
Counted across the registry records on this site, refreshed daily.
ASA Physical Status I-II
Scheduled for elective laparoscopic cholecystectomy
Able to provide written informed consent
Exclusion Criteria:
Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane)
Severe chronic obstructive pulmonary disease (COPD)
Uncontrolled bronchial asthma
Decompensated heart failure (NYHA Class III-IV)
History of prior lung surgery
Morbid obesity (BMI > 35 kg/m²)
Pregnancy
Refusal to participate or inability to provide informed consent
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Maintenance of general anesthesia with sevoflurane 2% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.
Drug: Sevoflurane
Maintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three standardized intraoperative time points under identical ventilator settings.
Drug: Desflurane
General anesthesia will be maintained with sevoflurane at 2% concentration in patients assigned to the Sevoflurane Group (Group S). Standardized ventilator settings will be applied for all participants, and mechanical power will be measured at three intraoperative time points while sevoflurane is used as the sole maintenance inhalational agent.
Also known as: Group S
Maintenance of general anesthesia with desflurane 6% during laparoscopic cholecystectomy. Mechanical power is measured at three intraoperative time points using standardized ventilator settings.
Mechanical Power (MP) during General Anesthesia
Time frame: Measured at three intraoperative time points: Post-intubation baseline (MP1) 15 minutes after pneumoperitoneum (MP2) End of surgery before emergence (MP3)
Plan to share: No
This study is completed, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Konya City Hospital