An interventional study of Vagus nerve stimulation (VNS) paired with mobility training in Ischemic Stroke, sponsored by Mayo Clinic. Recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-02-17.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Treatment
The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.
2,593 studies on the registry are indexed under Ischemic Stroke; 930 are open to participants now.
This study's planned enrollment of 20 is below the median of 120 across 1,752 interventional studies indexed under Ischemic Stroke.
Browse Ischemic Stroke studies →Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants with chronic ischemic stroke will be treated with a combination of vagus nerve stimulation and mobility training.
Other: Vagus nerve stimulation (VNS) paired with mobility training
Participants will complete a 6-week in-clinic therapy phase (3 sessions per week), where a physical therapist will lead mobility training with VNS delivered via a handheld magnet. This will be followed by a 6-week at-home phase where participants continue daily exercises and VNS use, supported by weekly video calls to review at home rehabilitation activity and wearable activity monitors for remote monitoring.
Number of serious adverse events related to vagus nerve stimulation or therapy
Total number of serious adverse events reported related to vagus nerve stimulation (VNS) or mobility training
Time frame: 1 year
Number of participants to complete the study
Total number of participants to complete a minimum of 18 therapy sessions
Time frame: 1 year
Change in Instrumented Gait Assessment score
Gait speed is calculated as the predetermined distance divided by the time to walk that distance, reported in meters per second (m/s). Improvement in gait velocity is ≥0.05 m/s .
Time frame: Baseline, 12 months
Plan to share: No
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