ClinicalTrials.gg
Enrolling by invitationNCT07280221Updated Sep 30, 2026

WEgovy Real World Assessment of Weight Loss in Korea

An observational study in Obesity, sponsored by Novo Nordisk A/S. Enrolling by invitation at 18 sites in South Korea. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2026-09-30.

Sponsored by Novo Nordisk A/S · Observational

Updated Sep 30, 202617 sites addedGo to Updates ↓

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Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
500
Ages
19 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 207 studies in Obesity by Novo Nordisk A/S — 48 open to participants now, 66 under way, 26 of them phase 3. Obesity · Novo Nordisk A/S.

Planned enrollment
31st of 41
500 · median 1,260
Started
2025
with 21 others
Observational
41 of 207
8 open now
Primary completion
2027-10
later than 28 of 65 live
Registered
159th of 207
by date

Among the 207 studies in Obesity by Novo Nordisk A/S, this one is the 31st largest by planned enrollment of the 41 observational ones that give a count, is one of 22 that started in 2025, is one of 41 observational ones, reaches primary completion later than 28 of the 65 other live ones, and was the 159th registered.

Obesity

11,536 studies on the registry are indexed under Obesity; 2,042 are open to participants now.

Browse Obesity studies →

Open to participants now

48 of the 207 studies in Obesity by Novo Nordisk A/S are open now, in 12 countries. Recruiting first, the newest first:

43 more — sign in →

By country, each count listing its studies:

All 48 open studies →

Who these studies take

Of the 1,339 Obesity studies recruiting now, 377 (28%) set no upper age limit and 859 (64%) stop at 75 or younger; 167 take children under 18; 490 take healthy volunteers.

This study: 19 Years and older · all sexes · no healthy volunteers.

The full table on the hub →

This tab as a report to print or save as PDF → With an account.

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Watch this landscapeDownload CSVNarrow it in search →With an account: a weekly mail of what changed among 207 studies in Obesity by Novo Nordisk A/S, or all of them as a file.
02

Study summary

This study is to investigate the effectiveness and safety of Wegovy (semaglutide) in Korean patients living with obesity in routine clinical practice. The purpose of this study is to investigate the change in body weight and other clinical characteristics related to body weight in patients living with obesity. Participants will be treated with Wegovy (semaglutide) as prescribed by their doctor, in accordance with normal clinical practice. The study will last for about 52 weeks.

03

Conditions studied

  • Obesity

Browse trials for

04

Who can participate

Ages eligible
19 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Participants will be treated with commercially available semaglutide. The treating physician will initiate treatment with commercially available semaglutide prior to and independently from the decision to include the participant in the study.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Signed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol).
  2. The decision to initiate treatment with commercially available Wegovy (semaglutide) has been made by the patient and the treating physician before and independently from the decision to include the patient in this study.
  3. Initiating treatment with Wegovy (semaglutide) for the first time and according to locally approved label.
  4. Male or female, aged ≥ 19 years at the time of signing the .

Exclusion criteria

Exclusion Criteria:

  1. Previous participation in clinical studies including treatment with Wegovy (semaglutide). Participation is defined as providing in a previous study.
  2. Female patient who is pregnant, breast-feeding, or intends to become pregnant and is of not using adequate methods (adequate contraceptive measures as required by local regulation or practice).
  3. Mental incapacity, unwillingness or language barriers precluding adequate understanding or co-operation.
Terms in these criteria, in plain language(3)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Childbearing potential

Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).

Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.

Contraception

Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.

Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.

05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
500 participants (estimated)
Patient registry
No

Groups and cohorts

  • Once weekly Wegovy

    Participants will be treated with commercially available semaglutide. The treating physician will initiate treatment with commercially available semaglutide prior to and independently from the decision to include the participant in the study.

    Drug: Semaglutide

Interventions

  • Semaglutide injection will be self-administered once weekly subcutaneously.

06

What researchers measure

Primary outcomes

  1. Percentage change in body weight

    Percent (%)

    Time frame: From baseline (week 0) to 24 weeks

Secondary outcomes

  1. Absolute change in body weight

    Kilogram (kg)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  2. Percentage change in body weight

    Percent (%)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  3. Achievement in body weight reduction more than or equal to (≥) 5%

    Count of patients

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  4. Achievement in body weight reduction ≥ 10%

    Count of patients

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  5. Achievement in body weight reduction ≥ 15%

    Count of patients

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  6. Achievement in body weight reduction ≥ 20%

    Count of patients

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  7. Change in body composition of Lean body mass

    Kg

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  8. Change in body composition of Total fat mass

    Kg

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  9. Change in body composition of Lean body mass

    Percent (%)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  10. Change in body composition of Total fat mass

    Percent (%)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  11. Change in Body mass index (BMI)

    Kilogram per meter square (kg/m\^2)

    Time frame: From baseline (week 0) up to 8, 16, 24, 32, 40, 52 weeks

  12. Change in the proportion of patients by BMI Class I obesity (25 to 29.9 kg/m^2)

    Count of patients

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  13. Change in the proportion of patients by BMI Class II obesity (30 to 34.9 kg/m^2)

    Count of patients

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  14. Change in the proportion of patients by BMI Class III obesity (≥35 kg/m^2)

    Count of patients

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  15. Change in waist circumference

    Centimetre (cm)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  16. Change in cardiometabolic parameters - Systolic blood pressure (SBP)

    Millimetres of mercury (mmHg)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  17. Change in cardiometabolic parameters - Diastolic blood pressure (DBP)

    mmHg

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  18. Change in cardiometabolic parameters - Fasting plasma glucose (FPG)

    Milligram per deciliter (mg/dL)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  19. Change in cardiometabolic parameters - Haemoglobin A1c (HbA1c)

    Percent (%)

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  20. Change in cardiometabolic parameters - Lipids: total cholesterol (TCh)

    mg/dL

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  21. Change in cardiometabolic parameters - Lipids: high-density lipoprotein cholesterol (HDL-C)

    mg/dL

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  22. Change in cardiometabolic parameters - Lipids: low-density lipoprotein cholesterol (LDL-C)

    mg/dL

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  23. Change in cardiometabolic parameters - Lipids: triglycerides (TG)

    mg/dL

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  24. Change in cardiometabolic parameters - Lipids: free fatty acid (FFA)

    mg/dL

    Time frame: From baseline (week 0) to 8, 16, 24, 32, 40, 52 weeks

  25. Change in status of type two diabetes mellitus (T2DM)

    Count of patients

    Time frame: Baseline (week 0) to 52 weeks [or end of the study (EOS)]

  26. Change in status of Hypertension

    Count of patients

    Time frame: Baseline (week 0) to 52 weeks (or EOS)

  27. Change in status of Dyslipidemia

    Count of patients

    Time frame: Baseline (week 0) to 52 weeks (or EOS)

  28. Number of treatment-emergent adverse events (TEAEs)

    Count of events

    Time frame: From baseline (week 0) to 52 weeks (or EOS)

  29. Number of serious TEAEs

    Count of events

    Time frame: From baseline (week 0) to 52 weeks (or EOS)

07

Study locations

18 sites
08

References and documents

Individual participant data

Plan to share: Yes — According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

Data sharing details ↗ · novonordisk-trials.com

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Nov 2025 (actual). Primary completion is estimated for Oct 2027, 23 months after the start.

Of 45 industry-sponsored observational studies under Obesity, half reached primary completion within 25 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 45. This study's planned 23 months is close to that.

Counting every sponsor, half of 838 studies reached it within 39 months; a quarter within 17 and three quarters within 96.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 24, 2025
First posted
Dec 12, 2025
StartActual
Nov 10, 2025
Primary completionEst.
Oct 31, 2027
CompletionEst.
Oct 31, 2027
Last update
Sep 30, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Sites
17 sites added
Show 17 added (17 South Korea)
  • National Health Insurance Corporation Ilsan Hospital · Goyang-si, South Korea
  • Seoul National University Bundang Hospital · Seongnam-si, South Korea
  • Ajou University Hospital · Suwon, South Korea
  • The Catholic University of Korea. Uijeongbu St. Mary's Hospital · Uijeongbu-si, South Korea
  • Pusan National University Yangsan Hospital · Yangsan, South Korea
  • Inje University Haeundae Paik Hospital · Busan, South Korea
  • Dong-A University Hospital · Busan, South Korea
  • Keimyung University Dongsan Hospital · Daegu, South Korea
  • Konyang University Hospital · Daejeon, South Korea
  • Chung-Ang University Gwangmyeong Hospital · Gwangmyeong-si, Gyeonggi-do, South Korea
  • CHA Bundang Medical Center · Seongnam-si, Gyeonggi-do, South Korea
  • Seoul Happiness Clinic of internal medicine · Seongnam-si, Gyeonggi-do, South Korea
  • Chung-Ang University Hospital · Seoul, South Korea
  • Ewha Womans University Seoul Hospital · Seoul, South Korea
  • Korea University Guro Hospital · Seoul, South Korea
  • Uijeongbu Eulji university Hospital · Uijeongbu-si, Gyeonggi-do, South Korea
  • Yongin Severance Hospital · Yongin-si, South Korea
Sep 30, 2026
Show all 1 update
  1. Sep 30, 2026
    17 sites added
    Show 17 added (17 South Korea)
    • National Health Insurance Corporation Ilsan Hospital · Goyang-si, South Korea
    • Seoul National University Bundang Hospital · Seongnam-si, South Korea
    • Ajou University Hospital · Suwon, South Korea
    • The Catholic University of Korea. Uijeongbu St. Mary's Hospital · Uijeongbu-si, South Korea
    • Pusan National University Yangsan Hospital · Yangsan, South Korea
    • Inje University Haeundae Paik Hospital · Busan, South Korea
    • Dong-A University Hospital · Busan, South Korea
    • Keimyung University Dongsan Hospital · Daegu, South Korea
    • Konyang University Hospital · Daejeon, South Korea
    • Chung-Ang University Gwangmyeong Hospital · Gwangmyeong-si, Gyeonggi-do, South Korea
    • CHA Bundang Medical Center · Seongnam-si, Gyeonggi-do, South Korea
    • Seoul Happiness Clinic of internal medicine · Seongnam-si, Gyeonggi-do, South Korea
    • Chung-Ang University Hospital · Seoul, South Korea
    • Ewha Womans University Seoul Hospital · Seoul, South Korea
    • Korea University Guro Hospital · Seoul, South Korea
    • Uijeongbu Eulji university Hospital · Uijeongbu-si, Gyeonggi-do, South Korea
    • Yongin Severance Hospital · Yongin-si, South Korea
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07280221
Lead sponsor
Novo Nordisk A/S
Responsible party
Sponsor
First posted
Dec 12, 2025
Start date
Nov 10, 2025
Primary completion
Oct 31, 2027 (estimated)
Completion
Oct 31, 2027 (estimated)
Last update
Sep 30, 2026

Study contacts

Clinical Transparency dept. 2834
study director · Novo Nordisk A/S

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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