An observational study in Erectile Dysfunctions, Endothelial Dysfunction and Inflammation, sponsored by Ataturk University. Completed at 1 site in Turkey (Türkiye). Open to male participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-12-10.
Sponsored by Ataturk University · Observational
This retrospective single-center case-control study evaluates whether the Modified EASIX score (LDH × CRP / Platelets), calculated from routine blood tests, predicts severity of erectile dysfunction (ED) as measured by the IIEF-5 questionnaire. Medical records from January 1, 2024 to September 30, 2025 will be reviewed. Patients will be classified by IIEF-5 (≤21 = ED; ≥22 = no ED) and Modified EASIX distributions and predictive performance (ROC/AUC) will be compared between groups. No additional interventions will be performed.
This retrospective observational study will include adult male patients aged 18-65 attending the urology outpatient clinic. Demographic data, comorbidities, IIEF-5 scores and routine laboratory results (LDH, CRP, platelet count and other routine biochemistry/hematology) obtained during routine follow-up will be extracted from medical records covering January 2024-September 2025. The Modified EASIX score will be computed as: LDH × CRP / Platelets. Patients will be grouped according to IIEF-5: ED group (IIEF-5 ≤21) and non-ED group (IIEF-5 ≥22). Primary analyses include group comparisons of Modified EASIX, correlation analyses with IIEF-5, logistic regression for association and ROC analysis to evaluate discriminatory performance and optimal cut-offs. Analyses will use IBM SPSS 27 and GraphPad Prism 9. No changes to patient management were made for study purposes; no additional sampling or interventions were performed.
683 studies on the registry are indexed under Erectile Dysfunction; 117 are open to participants now.
This study's enrollment of 380 is above the median of 130 across 115 observational studies indexed under Erectile Dysfunction.
Browse Erectile Dysfunction studies →Ataturk University is the lead sponsor of 442 studies on the registry; 121 are open to participants now.
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Adult male patients aged 18-65 who attended the urology outpatient clinic and had documented IIEF-5 scores and routine laboratory results (LDH, CRP, platelet count) between January 2024 and September 2025. The study includes both patients with erectile dysfunction (IIEF-5 ≤ 21) and those without erectile dysfunction (IIEF-5 ≥ 22), using retrospectively collected medical records from a single center (Defne State Hospital).
Male patients aged 18-65. Followed at the urology outpatient clinic with a documented IIEF-5 questionnaire.
Available routine laboratory data including LDH, CRP and platelet count within the study period (Jan 1, 2024 - Sep 30, 2025).
Exclusion Criteria:
Use of penile prosthesis. Patients without an organic ED diagnosis when relevant (per protocol: "Patients without an organic ED diagnosis will be excluded from the study").
Missing essential data for Modified EASIX calculation or IIEF-5.
Erectile Dysfunction Group
Other: IIEF-5 · Other: mEASIX
Non-Erectile Dysfunction Group
Other: IIEF-5 · Other: mEASIX
IIEF-5: The erectile dysfunction status of patients will be analyzed with the International Index of Erectile Function-5.
Endothelial function will be evaluated with mEAX.
Difference in Modified EASIX score between ED and non-ED groups
Mean Modified EASIX (LDH × CRP / Platelets) in each group. Group comparison (t-test) and effect size.
Time frame: Retrospective records from Jan 1, 2024 to Sep 30, 2025.
Difference in Modified EASIX score between ED and non-ED groups
Median Modified EASIX (LDH × CRP / Platelets) in each group. Group comparison (Mann-Whitney U) and effect size.
Time frame: Time Frame: Retrospective records from Jan 1, 2024 to Sep 30, 2025.
Plan to share: No — Individual participant data (IPD) will not be publicly shared because the study is based on retrospective medical records containing sensitive personal health information. Due to privacy concerns and institutional data-protection regulations, de-identified datasets cannot be released outside the research team.
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
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Ataturk University