CClinicalTrials.gg
RecruitingNCT07273968SEREINUpdated Aug 20, 2026

Clinical Study Evaluating the Effect of Virtual Reality on Reducing Patients' Anxiety During Wisdom Teeth Extraction

An interventional study of Virtual reality HypnoVR® (VR headset + hypnotic software) and Control Group (No VR) in Dental Anxiety, Third Molar Extraction and Oral Surgery, sponsored by University Hospital, Strasbourg, France. Recruiting at 1 site in France. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-08-20.

Sponsored by University Hospital, Strasbourg, France · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Apr 2026; still recruiting 5 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Dental anxiety is common during third molar extractions and may exacerbate pain perception. Local anesthesia does not prevent exposure to stress-inducing stimuli. Virtual reality (VR) combined with hypnotic scripts (HypnoVR®) provides immersive multisensory distraction. This study tests whether VR reduces perioperative anxiety and postoperative pain compared to local anesthesia alone.

02

Conditions studied

  • Dental Anxiety
  • Third Molar Extraction
  • Oral Surgery
03

In context

Lead sponsor

University Hospital, Strasbourg, France is the lead sponsor of 968 studies on the registry; 344 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age 18-65
  • Indication for extraction of 4 wisdom teeth or ≥2 mandibular wisdom teeth
  • ASA I-II
  • Written informed consent.

Exclusion criteria

Exclusion criteria:

  • Visual/hearing impairment
  • Psychiatric disorders or psychotropics (\<8 weeks)
  • Claustrophobia
  • Heavy smoking >10 cig/day
  • Previous radiotherapy (jaw)
  • ASA III-IV
  • Pregnancy
  • Antithrombotic therapy
  • Chemotherapy
  • Bisphosphonates
  • Uncontrolled diabetes
  • Severe anxiety requiring GA or pharmacological sedation
  • No health insurance affiliation.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
60 participants (estimated)

Study arms

  • Experimental
    Virtual Reality Group

    Wisdom tooth extraction under local anesthesia with immersive VR hypnosis (HypnoVR® system).

    Device: Virtual reality HypnoVR® (VR headset + hypnotic software)

  • Active comparator
    Control Group (No VR)

    Wisdom tooth extraction under local anesthesia alone (no VR).

    Other: Control Group (No VR)

Interventions

  • DeviceVirtual reality HypnoVR® (VR headset + hypnotic software)

    CE-marked class I device combining VR immersion with hypnotic text and music therapy to reduce anxiety and pain during oral surgery.

  • OtherControl Group (No VR)

    local anesthesia alone (no VR)

06

What researchers measure

Primary outcomes

  1. Anxiety reduction (MDAS questionnaire)

    5-item validated scale, score range 5-25

    Time frame: Day 1

  2. Anxiety reduction (MDAS questionnaire)

    5-item validated scale, score range 5-25

    Time frame: Month1

07

Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 20, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07273968
Lead sponsor
University Hospital, Strasbourg, France
Responsible party
Sponsor
First posted
Dec 10, 2025
Start date
Apr 10, 2026
Primary completion
Sep 1, 2027 (estimated)
Completion
Sep 1, 2027 (estimated)
Last update
Aug 20, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

No contact was published for this record. The registry link below has the sponsor’s details.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion