An interventional study of Exercise in Health Adults, sponsored by Loughborough University. Enrolling by invitation at 1 site in United Kingdom. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-03.
Sponsored by Loughborough University · Not applicable, Interventional, and Basic science
The goal of this study is to investigate the acute effects of cricket fast bowling on the bone turnover and signaling markers in healthy young males.
The main question aims to answer:
Participants complete both the bowling and control trials, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 2-hour post bowling/rest.
Exclusion Criteria:
Participants first perform the bowling trial, followed by the control trial, with a minimum interval of one week between the two trials.
Behavioral: Exercise
Participants first perform the control trial, followed by the bowling trial, with a minimum interval of one week between the two trials.
Behavioral: Exercise
During the bowling trial, participants perform 8 sets of 6 deliveries (bowl at match intensity throughout), followed by 2-hour rest. Each set is interspersed by a 3-minute randomized fielding simulation. During the control trial, participants rest throughout instead of bowling.
Serum C-terminal telopeptide of type I collagen (CTX-I) concentration
Serum CTX-I concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum N-terminal propeptide of type I collagen (PINP) concentration
Serum PINP concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in nanograms per milliliter (ng/mL).
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum parathyroid hormone (PTH) concentration
Serum PTH concentration is measured using electrochemiluminescence immunoassay (ECLIA) and reported in picograms per milliliter (pg/mL).
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum sclerostin concentration
Serum sclerostin concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum dickkopf Wnt signaling pathway inhibitor 1 (DKK1) concentration
Serum DKK1 concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum osteoprotegerin (OPG) concentration
Serum OPG concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Serum irisin concentration
Serum irisin concentration is measured using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
Time frame: Blood samples are collected at baseline, immediately after the bowling or the corresponding rest period, and 2 hours after the second blood sample collection.
Bowling speed
Bowling speed is measured using a radar gun during the 8 overs of bowling and reported in miles per hour (MPH).
Time frame: Bowling speed is measured during the bowling trial.
Plan to share: No
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Loughborough University