An interventional study of Hot environment and Temperate condition in Plasma Glucose Following Prolonged Heat Exposure, sponsored by Loughborough University. Not yet recruiting. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-21.
Sponsored by Loughborough University · Not applicable, Interventional, and Basic science
Occupational workers regularly perform physically demanding tasks in hot environments, exposing them to heat stress and potential dehydration. While the physiological impacts of heat exposure are well-documented, its effects on glycemic control remain less understood. Given the rising global temperatures due to climate change and the increasing prevalence of metabolic disorders such as obesity and type 2 diabetes, it is essential to investigate how heat exposure during work influences glycemic regulation. Understanding these interactions will help inform future occupational health guidelines and metabolic health recommendations in physically demanding industries.
Exclusion Criteria:
Light exercise in a hot environment with ad libitum water intake
Other: Hot environment
Light exercise in a temperate environment with ad libitum water intake
Other: Temperate condition
Participants exercising in a 36 degrees celsius environment
Participants exercising in a 18 degrees celsius environment
Plasma glucose
Measured using colorimetric assay from venous blood samples
Time frame: 8hours
Plasma insulin
Measured using ELISA from venous blood samples
Time frame: 8hours
Plasma osmolality
Measured using freezing point depression from venous blood samples
Time frame: 8hours
Plasma volume change
Determined from haemoglobin and haematocrit measures in blood samples
Time frame: 8hours
Urine volume
Determined from urine samples collected before and after exercise
Time frame: 8hours
Body mass
Determined from weighing participants before and after exercise
Time frame: 8hours
Urine specific gravity/osmolality
Determined from urine samples collected before and after exercise
Time frame: 8hours
Rectal temperature
Measured via rectal probe
Time frame: 8hours
Blood pressure
Measured via and automated sphygmomanometer
Time frame: 8hours
Respiratory gas exchanges
Measured via Douglas bag, gas content and volume
Time frame: 8hours
Rate of perceived exertion
using Borg scales (from 6 \[no effort\] to 20 \[maximal effort\])
Time frame: 8hours
Rate of thermal sensation
using -10 \[cold\] to +10 \[hot\] scale.
Time frame: 8hours
Feelings of thirst, urge to urinate, GI comfort, and stomach bloatedness
using scales (0 = no feeling, 10 = extreme feeling)
Time frame: 8hours
N-back task for working memory (cognitive function)
The task will comprise three progressively harder memory loads (1-Back, 2-Back, 3-Back). Each stimulus type will be used in all memory loads. Participants will have to respond using the space bar when they see a stimulus that is presented one, two, or three steps previously, dependent on the load condition.
Time frame: 8hours
Go/no-go task for response inhibition (cognitive function)
Participants will be instructed to press the space bar when a green image appears onscreen ("go" stimulus) and to inhibit responding when a red image is presented (the "no-go" stimulus). Increased commission error responses (i.e. responding incorrectly on a no-go trial) will indicate reduced response inhibition. Commission errors and correct responses will be measured as indices of performance.
Time frame: 8hours
Stroop test
The Stroop Test is a psychological assessment that measures a person's ability to inhibit cognitive interference and control attention. Typically, it involves naming the color of the ink in which a word is printed, even when the word itself names a different color (e.g., the word "red" printed in blue ink). The delay in response time when the word and ink color do not match-known as the Stroop effect-reflects the difficulty of suppressing automatic cognitive processes.
Time frame: 8hours
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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Loughborough University